Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Marengo E et al. | Evaluation of the variables characterized by significant discriminating power in the application of SIMCA classification method to proteomic studies. | 2008 | J. Proteome Res. | pmid:18543959 |
Lecona E et al. | Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase. | 2008 | Mol. Cell. Biol. | pmid:18541673 |
Gavin DP et al. | Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. | 2008 | Schizophr. Res. | pmid:18539439 |
Jiang X et al. | DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. | 2008 | Cancer Cell | pmid:18538736 |
Hoffmann K et al. | Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases? | 2008 | Epilepsy Res. | pmid:18538545 |
Makki MS et al. | TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. | 2008 | Nucleic Acids Res. | pmid:18535006 |
Chung KS et al. | Fission yeast-based screening to identify putative HDAC inhibitors using a telomeric reporter strain. | 2008 | Mol. Cells | pmid:18525239 |
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Pan J et al. | TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells. | 2008 | Mol. Cancer Res. | pmid:18505930 |
Cao W et al. | Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. | 2008 | J. Exp. Med. | pmid:18504304 |
Ma P and Schultz RM | Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. | 2008 | Dev. Biol. | pmid:18501342 |
Sun C and Zhou J | Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2. | 2008 | Biochem. Pharmacol. | pmid:18495085 |
Chen Y et al. | A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. | 2008 | J. Med. Chem. | pmid:18494463 |
Chu F et al. | Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway. | 2008 | Aging Cell | pmid:18489729 |
Egler V et al. | Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death. | 2008 | Clin. Cancer Res. | pmid:18483381 |
Dalgard CL et al. | Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. | 2008 | Clin. Cancer Res. | pmid:18483379 |
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Mackay CL et al. | Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4. | 2008 | Anal. Chem. | pmid:18457408 |
Moynihan AT et al. | Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility. | 2008 | Am. J. Obstet. Gynecol. | pmid:18455134 |
Geli J et al. | Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma. | 2008 | Int. J. Cancer | pmid:18452173 |
van West P et al. | Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling. | 2008 | Microbiology (Reading, Engl.) | pmid:18451057 |
Jensen TJ et al. | Epigenetic remodeling during arsenical-induced malignant transformation. | 2008 | Carcinogenesis | pmid:18448484 |
Yu C et al. | Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. | 2008 | Neuro-oncology | pmid:18445700 |
Xu LN et al. | Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines. | 2008 | World J. Gastroenterol. | pmid:18442209 |
Zhang HJ et al. | Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. | 2008 | Placenta | pmid:18440631 |
Kikuno N et al. | Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. | 2008 | Int. J. Cancer | pmid:18431742 |
Mazitschek R et al. | Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18430569 |
Sebastián C et al. | Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. | 2008 | J. Immunol. | pmid:18424709 |
Meja KK et al. | Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18421014 |
Habold C et al. | Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. | 2008 | J. Cell. Mol. Med. | pmid:18419600 |
Iager AE et al. | Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos. | 2008 | Cloning Stem Cells | pmid:18419249 |
Jeseta M et al. | In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A. | 2008 | Zygote | pmid:18405435 |
Kaipparettu BA et al. | Estrogen-mediated downregulation of CD24 in breast cancer cells. | 2008 | Int. J. Cancer | pmid:18404683 |
Kawamoto K et al. | DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines. | 2008 | Int. J. Cancer | pmid:18404682 |
Roy S et al. | Histone deacetylase 5 represses the transcription of cyclin D3. | 2008 | J. Cell. Biochem. | pmid:18404677 |
Ko JM et al. | Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. | 2008 | Mol. Cancer Res. | pmid:18403638 |
Yan C et al. | Comparative molecular dynamics simulations of histone deacetylase-like protein: binding modes and free energy analysis to hydroxamic acid inhibitors. | 2008 | Proteins | pmid:18398905 |
Chen PC et al. | Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group. | 2008 | Bioorg. Med. Chem. | pmid:18397827 |
Nakao Y et al. | Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18397826 |
Qi J et al. | [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18396643 |
Galiová G et al. | Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. | 2008 | Eur. J. Cell Biol. | pmid:18396346 |
Karantzali E et al. | Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis. | 2008 | Genome Biol. | pmid:18394158 |
Liu TC et al. | Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. | 2008 | Mol. Ther. | pmid:18388912 |
Rebbaa A et al. | Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent. | 2008 | Angiogenesis | pmid:18386142 |
Pandey SC et al. | Brain chromatin remodeling: a novel mechanism of alcoholism. | 2008 | J. Neurosci. | pmid:18385331 |
Lin YC et al. | Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. | 2008 | Cancer Res. | pmid:18381445 |
Xu ZM et al. | The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage. | 2008 | BMB Rep | pmid:18377727 |
Lindström TM et al. | Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells. | 2008 | Mol. Pharmacol. | pmid:18375836 |
Biacsi R et al. | SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. | 2008 | PLoS Genet. | pmid:18369442 |
Vrbova G | Spinal muscular atrophy: motoneurone or muscle disease? | 2008 | Neuromuscul. Disord. | pmid:18365338 |
Brown SL et al. | Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. | 2008 | Radiat. Res. | pmid:18363436 |
Mukherjee P et al. | Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. | 2008 | Bioorg. Med. Chem. | pmid:18362073 |
Svechnikova I et al. | HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. | 2008 | Int. J. Oncol. | pmid:18360709 |
Wei Q et al. | [Effect of trichostatin A on proliferation and interleukin-2 expression of mouse T cells in mixed lymphocyte culture]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18359716 |
Henkens T et al. | Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes. | 2008 | Toxicol. Lett. | pmid:18358644 |
Kimata Y et al. | Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. | 2008 | J. Cell. Sci. | pmid:18354085 |
Balakrishnan L and Milavetz B | HDAC inhibitors stimulate viral transcription by multiple mechanisms. | 2008 | Virol. J. | pmid:18353181 |
Borghol N et al. | Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes. | 2008 | Genomics | pmid:18343090 |
Countryman JK et al. | Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors. | 2008 | J. Virol. | pmid:18337569 |
Fantini D et al. | APE1/Ref-1 regulates PTEN expression mediated by Egr-1. | 2008 | Free Radic. Res. | pmid:18324520 |
Fleury L et al. | Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. | 2008 | Oncogene | pmid:18317449 |
Brown CR et al. | Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. | 2008 | Genes Dev. | pmid:18316479 |
Kim M et al. | Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. | 2008 | Mol. Cancer Res. | pmid:18314483 |
Dong G et al. | Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18310471 |
Jiang Y et al. | Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes. | 2008 | J. Exp. Biol. | pmid:18310117 |
Suuronen T et al. | Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90. | 2008 | Neurochem. Res. | pmid:18307035 |
Lin W et al. | Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. | 2008 | Genes Cells | pmid:18298800 |
Horswill MA et al. | Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts. | 2008 | Exp. Eye Res. | pmid:18291368 |
Schuetz A et al. | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. | 2008 | J. Biol. Chem. | pmid:18285338 |
Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
Oliva J et al. | Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. | 2008 | Exp. Mol. Pathol. | pmid:18280469 |
Kovács P et al. | Effect of histone deacetylase inhibitor trichostatin A (TSA) on the microtubular system of Tetrahymena. | 2007 | Acta. Biol. Hung. | pmid:18277464 |
Kang JH et al. | CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. | 2008 | J. Cell. Biochem. | pmid:18275041 |
Sasaki K et al. | Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera. | 2008 | Cancer Sci. | pmid:18271940 |
Shi LH et al. | Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. | 2008 | Dev. Dyn. | pmid:18265023 |
Fan J et al. | ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. | 2008 | J. Cancer Res. Clin. Oncol. | pmid:18264725 |
Politis PK et al. | BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells. | 2008 | FEBS Lett. | pmid:18258204 |
Mazzarelli P et al. | Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? | 2007 | Cancer Biol. Ther. | pmid:18253084 |
Gupta MP et al. | HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. | 2008 | J. Biol. Chem. | pmid:18250163 |
Paris M et al. | Histone deacetylase inhibitors: from bench to clinic. | 2008 | J. Med. Chem. | pmid:18247554 |
Shi LH et al. | Trichostatin A and nuclear reprogramming of cloned rabbit embryos. | 2008 | J. Anim. Sci. | pmid:18245503 |
Li X et al. | The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. | 2008 | Cloning Stem Cells | pmid:18241125 |
Wang Q et al. | The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis. | 2008 | Cell Cycle | pmid:18239470 |
Tang Y et al. | Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. | 2008 | Circ. Res. | pmid:18239137 |
Yildirim F et al. | Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. | 2008 | Exp. Neurol. | pmid:18234195 |
Lim HG et al. | Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. | 2008 | Mol. Ther. | pmid:18227841 |
Nasu Y et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. | 2008 | Osteoarthr. Cartil. | pmid:18226559 |
Kuwajima A et al. | The histone deacetylase inhibitor butyrate inhibits melanoma cell invasion of Matrigel. | 2007 Nov-Dec | Anticancer Res. | pmid:18225587 |
Yasuda K et al. | ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells. | 2007 Nov-Dec | Anticancer Res. | pmid:18225573 |
Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
Andrews KT et al. | Potent antimalarial activity of histone deacetylase inhibitor analogues. | 2008 | Antimicrob. Agents Chemother. | pmid:18212103 |
Yu WP et al. | Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells. | 2008 | Cell Prolif. | pmid:18211287 |
Duhamel M et al. | Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. | 2008 | FEBS Lett. | pmid:18206652 |
Hamner JB et al. | The efficacy of combination therapy using adeno-associated virus--interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. | 2008 | J. Pediatr. Surg. | pmid:18206478 |
Serrano E et al. | Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. | 2008 | Leuk. Res. | pmid:18206229 |
Ruau D et al. | Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. | 2008 | Stem Cells | pmid:18203677 |
Isakov E et al. | Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica. | 2008 | Mol. Biochem. Parasitol. | pmid:18191469 |
Heller G et al. | Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells. | 2008 | Cancer Res. | pmid:18172295 |
Wu ZQ et al. | Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. | 2007 | Chin. Med. J. | pmid:18167185 |
Joseph RA et al. | Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking. | 2008 | Hepatology | pmid:18161881 |