trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Song YF et al. | High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. | 2006 | J. Clin. Pathol. | pmid:16489177 |
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| Endo T et al. | Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes. | 2006 | Reproduction | pmid:16514187 |
| Sah NK et al. | Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. | 2006 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:17011457 |
| Kumar KS et al. | Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. | 2006 | Oncol. Rep. | pmid:17016591 |
| Alao JP et al. | Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:17018141 |
| Zhao LY et al. | An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. | 2006 | Cancer Res. | pmid:17018599 |
| Mogal A and Abdulkadir SA | Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. | 2006 | Mol. Cell. Probes | pmid:16326072 |
| Gan Y et al. | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16338217 |
| Nishiyama A et al. | Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. | 2006 | Mol. Biol. Cell | pmid:16339075 |
| Solomon JM et al. | Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. | 2006 | Mol. Cell. Biol. | pmid:16354677 |
| Kishigami S et al. | Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16356478 |
| Baradari V et al. | Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. | 2006 | Endocr. Relat. Cancer | pmid:17158768 |
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| Lau QC et al. | RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. | 2006 | Cancer Res. | pmid:16818622 |
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| Das PM et al. | Methylation mediated silencing of TMS1/ASC gene in prostate cancer. | 2006 | Mol. Cancer | pmid:16848908 |
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| Cecconi D et al. | Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335935 |
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| Kook SH et al. | Epstein-Barr virus-infected Akata cells are sensitive to histone deacetylase inhibitor TSA-provoked apoptosis. | 2005 | J. Biochem. Mol. Biol. | pmid:16336792 |
| Li XX et al. | Function of c-Fos-like and c-Jun-like proteins on trichostatin A-induced G2/M arrest in Physarum polycephalum. | 2005 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:16270156 |
| Francia G et al. | Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents. | 2005 | Mol. Cancer Ther. | pmid:16227397 |
| Chou SD et al. | Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. | 2005 | Int. Immunol. | pmid:16210330 |
| Bai Y et al. | Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. | 2005 | J. Immunol. | pmid:16210620 |
| Chen G et al. | [Enhancive effect of histone deacetylase inhibitor trichostatin a on transfection efficiency of adenovirus in ovarian carcinoma cell line A2780]. | 2005 | Ai Zheng | pmid:16219132 |
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| Valenzuela-Fernández A et al. | Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. | 2005 | Mol. Biol. Cell | pmid:16148047 |
| Davis FJ et al. | Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15388503 |
| Curtin BF et al. | Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. | 2005 | J. Cell. Biochem. | pmid:16149071 |
| Chen JS and Faller DV | Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. | 2005 | J. Cell. Physiol. | pmid:15389542 |
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| Johnson J et al. | Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid. | 2005 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:16171558 |
| Karagiannis TC et al. | The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X. | 2005 | Cancer Biol. Ther. | pmid:16082178 |
| Xiong Y et al. | Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. | 2005 | Gynecol. Oncol. | pmid:16024066 |
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| Tong X et al. | Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. | 2005 | J. Biol. Chem. | pmid:15713675 |
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| Robbins AR et al. | Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin. | 2005 | Cell Cycle | pmid:15846093 |
| Taghiyev AF et al. | Trichostatin A (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment. | 2005 | Cancer Biol. Ther. | pmid:15846101 |
| Barki-Celli L et al. | Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements. | 2005 | Genes Chromosomes Cancer | pmid:15846776 |
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| Choi YH | Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. | 2005 | Int. J. Oncol. | pmid:16010430 |
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| Rahmani M et al. | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. | 2005 | Cancer Res. | pmid:15781658 |
| Frescas D et al. | Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. | 2005 | J. Biol. Chem. | pmid:15788402 |
| Kang J et al. | Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. | 2005 | Biochem. Pharmacol. | pmid:15794941 |
| Narayanan R et al. | Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. | 2005 | Mol. Cell. Biol. | pmid:15798179 |
| Koh SH et al. | Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15752760 |
| Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
| Dowling M et al. | Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. | 2005 | Cancer Biol. Ther. | pmid:15753652 |