trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Zhang Z et al. Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride. 2017 Toxicol. Appl. Pharmacol. pmid:29054681
Nagaraja SS et al. Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549 cells. 2017 Biochem. Biophys. Res. Commun. pmid:28993195
Zheng C et al. Histone Deacetylase Inhibitors Relax Mouse Aorta Partly through Their Inhibitory Action on L-Type Ca Channels. 2017 J. Pharmacol. Exp. Ther. pmid:28860353
Jorstad NL et al. Stimulation of functional neuronal regeneration from Müller glia in adult mice. 2017 Nature pmid:28746305
Fujikawa J et al. Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes. 2017 Cell Tissue Res. pmid:28856432
Jiang F et al. Trichostatin A increases embryo and green plant regeneration in wheat. 2017 Plant Cell Rep. pmid:28752355
Jayaraman A et al. The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord. 2017 Neurobiol. Dis. pmid:28736194
Ikeda K et al. In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model. 2017 Sci Rep pmid:28300163
Anantharaju PG et al. Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). 2017 PLoS ONE pmid:29190639
Ilicic M et al. Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium. 2017 Biomed Res Int pmid:28540297
Duan HY et al. Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line. 2017 Chin. Med. J. pmid:28524836
Wei W et al. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. 2017 Cell Res. pmid:28497810
Acun T et al. HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer. 2017 OMICS pmid:28481734
Dai Q et al. Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. 2016 Acta Pharmacol. Sin. pmid:26775659
Rong X et al. Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. 2016 Sci Rep pmid:27703255
Bricambert J et al. Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. 2016 Mol Metab pmid:27900262
Duffy S et al. Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:27551064
Xu Q et al. Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:27638876
Nadanaka S et al. Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. 2016 Biochem. Biophys. Res. Commun. pmid:27751852
Tiper IV and Webb TJ Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. 2016 Cancer Immunol. Immunother. pmid:27614429
Morinobu A et al. Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. 2016 PLoS ONE pmid:27736946
Hrgovic I et al. The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. 2016 BMC Cancer pmid:27716272
Sobue S et al. Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. 2016 Biochem. Biophys. Res. Commun. pmid:27687545
Zhang Q et al. Trichostatin A protects against intestinal injury in rats with acute liver failure. 2016 J. Surg. Res. pmid:27620992
Desjardins D et al. Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. 2016 PLoS ONE pmid:27617745
Park IH et al. Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. 2016 PLoS ONE pmid:27571418
Zhang NH et al. Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. 2016 Oncol. Rep. pmid:27373420
Chang I and Wang CY Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. 2016 J. Biol. Chem. pmid:27369083
Yagi K et al. Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. 2016 Crit. Care Med. pmid:27352127
Wei L et al. Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. 2016 Brain Res. pmid:27312092
Hakami NY et al. Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis. 2016 J. Cell. Mol. Med. pmid:27297729
Raju I et al. Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. 2016 Biol. Chem. pmid:27279059
Somanna NK et al. Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation. 2016 Hypertens. Res. pmid:27278287
Kang HR et al. Butyrate-mediated acquisition of chemoresistance by human colon cancer cells. 2016 Oncol. Rep. pmid:27277338
Agudelo M et al. Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. 2016 PLoS ONE pmid:27249803
Allgayer J et al. Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine. 2016 Nucleic Acids Res. pmid:27220469
Du R et al. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. 2016 Mol Med Rep pmid:27121018
Kuan CS et al. Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. 2016 PLoS ONE pmid:26807725
Noh H et al. Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. 2016 Biochem. Biophys. Res. Commun. pmid:26768368
Hosseini SM et al. Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. 2016 BMC Genomics pmid:26725231
Lee K et al. Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis. 2016 J. Plant Physiol. pmid:26724747
Calvert S et al. A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. 2016 Aging Cell pmid:26676933
Zhang Q et al. Trichostatin A inhibits inflammation in phorbol myristate acetate‑induced macrophages by regulating the acetylation of histone and/or non‑histone proteins. 2016 Mol Med Rep pmid:26647731
Kikuchi M et al. Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. 2016 Oncotarget pmid:26646320
Trifunović D et al. HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. 2016 Hum. Mol. Genet. pmid:28172811
Vargas-López V et al. Histone deacetylase inhibition abolishes stress-induced spatial memory impairment. 2016 Neurobiol Learn Mem pmid:27544851
Piao J et al. Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC. 2016 Oncotarget pmid:27507059
Meng Z et al. PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. 2016 Oncogene pmid:26279303
Pang X et al. Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. 2016 Tumour Biol. pmid:26264615
Kim SH et al. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. 2016 Endocrine pmid:26219406