Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Oliveira CS et al. | HDAC inhibition decreases XIST expression on female IVP bovine blastocysts. | 2013 | Reproduction | pmid:23104973 |
Lakshmi SV et al. | Oxidative stress in coronary artery disease: epigenetic perspective. | 2013 | Mol. Cell. Biochem. | pmid:23160801 |
Jackson MF et al. | Genetic manipulation of myoblasts and a novel primary myosatellite cell culture system: comparing and optimizing approaches. | 2013 | FEBS J. | pmid:23173931 |
Bianco C et al. | Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23129342 |
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Pelascini LP et al. | Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. | 2013 | Hum. Gene Ther. | pmid:23140481 |
You BR and Park WH | Trichostatin A induces apoptotic cell death of HeLa cells in a Bcl-2 and oxidative stress-dependent manner. | 2013 | Int. J. Oncol. | pmid:23165748 |
Ogura A et al. | Recent advancements in cloning by somatic cell nuclear transfer. | 2013 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23166393 |
Dom G et al. | 5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro. | 2013 | Thyroid | pmid:23167291 |
Soriano FX et al. | SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites. | 2013 | J. Neurochem. | pmid:23083128 |
Culley KL et al. | Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. | 2013 | Arthritis Rheum. | pmid:23575963 |
Brown CO et al. | Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma. | 2013 | Leuk. Res. | pmid:23537707 |
Gang H et al. | Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23585133 |
Yacqub-Usman K et al. | Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes. | 2013 | Endocrinology | pmid:23539512 |
Khan DH and Davie JR | HDAC inhibitors prevent the induction of the immediate-early gene FOSL1, but do not alter the nucleosome response. | 2013 | FEBS Lett. | pmid:23542037 |
Chen J et al. | Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. | 2013 | Toxicol Ind Health | pmid:22294440 |
Wang F et al. | HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9. | 2013 | Clin Invest Med | pmid:23544610 |
Poplineau M et al. | Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells. | 2013 | Cell Prolif. | pmid:23510467 |
Ding SZ et al. | Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23518002 |
Azechi T et al. | Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. | 2013 | J. Atheroscler. Thromb. | pmid:23518467 |
Duncan HF et al. | Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. | 2013 | Exp. Cell Res. | pmid:23562654 |
Humphreys KJ et al. | Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. | 2013 | Mol. Carcinog. | pmid:22308110 |
Gao B et al. | Inhibition of histone deacetylase activity suppresses IFN-γ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. | 2013 | J. Immunol. | pmid:23729439 |
Luo B et al. | A possible strategy to produce pigs resistant to porcine reproductive and respiratory syndrome virus. | 2013 | Antiviral Res. | pmid:23732571 |
Tigges J et al. | Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. | 2013 | J. Invest. Dermatol. | pmid:22951721 |
Doñas C et al. | Trichostatin A promotes the generation and suppressive functions of regulatory T cells. | 2013 | Clin. Dev. Immunol. | pmid:23737814 |
Flight MH | Behaviour: epigenetically bonded. | 2013 | Nat. Rev. Neurosci. | pmid:23756635 |
Zhao TC et al. | HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. | 2013 | PLoS ONE | pmid:23762381 |
Saha A et al. | Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity. | 2013 | Bioorg. Med. Chem. | pmid:23719282 |
Doherty R et al. | Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC). | 2013 | Vet. Immunol. Immunopathol. | pmid:23764468 |
Liu J et al. | Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. | 2013 | Sci Rep | pmid:23378917 |
Shah RR et al. | Regulation of primitive hematopoiesis by class I histone deacetylases. | 2013 | Dev. Dyn. | pmid:23184530 |
Gao SM et al. | Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. | 2013 | Exp. Hematol. | pmid:23111066 |
Liu RF et al. | Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. | 2013 | Cancer Lett. | pmid:23142219 |
Jang SM et al. | Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916609 |
BurlibaÅŸa L and Zarnescu O | In vivo effects of Trichostatin A - A histone deacetylase inhibitor - On chromatin remodeling during Triturus cristatus spermatogenesis. | 2013 | Anim. Reprod. Sci. | pmid:24100069 |
Kang KA et al. | Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. | 2013 | Int. J. Oncol. | pmid:24100442 |
Moldrich RX et al. | Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. | 2013 | Behav. Brain Res. | pmid:24103642 |
Yamamura A et al. | Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24134849 |
Xu M et al. | Histone deacetylase inhibitors induce human renal cell carcinoma cell apoptosis through p-JNK activation. | 2013 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:24144737 |
Peng L et al. | [Tricostantin A inhibits self-renewal of breast cancer stem cells in vitro]. | 2013 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:24144739 |
Chen X et al. | The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells. | 2013 | Cell Death Dis | pmid:24157878 |
Liu YQ et al. | Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. | 2013 | Genet. Mol. Res. | pmid:24089095 |
Florea AM | DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals. | 2013 | Biomed Res Int | pmid:24093099 |
Liu S et al. | Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. | 2013 | Ann. Surg. Oncol. | pmid:22752337 |
Ononye SN et al. | Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors. | 2013 | ACS Med Chem Lett | pmid:24900743 |
Wang X et al. | Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. | 2013 | Mol. Carcinog. | pmid:22121107 |
Diao JS et al. | Histone deacetylase inhibitor reduces hypertrophic scarring in a rabbit ear model. | 2013 | Plast. Reconstr. Surg. | pmid:23806955 |
Sharma A et al. | Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. | 2013 | Carcinogenesis | pmid:23880304 |
Li Y et al. | Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. | 2013 | Mol. Cancer | pmid:23379261 |
Jiao F et al. | Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. | 2013 | Stem Cells Dev. | pmid:23750509 |
Tian Y et al. | Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. | 2013 | PLoS ONE | pmid:24367661 |
Jung AR et al. | Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment. | 2013 | Anticancer Res. | pmid:23482750 |
Piazza R et al. | Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. | 2013 | Neoplasia | pmid:23633923 |
Frame FM et al. | HDAC inhibitor confers radiosensitivity to prostate stem-like cells. | 2013 | Br. J. Cancer | pmid:24220693 |
Jagirdar K et al. | The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. | 2013 | PLoS ONE | pmid:24223135 |
Hu X et al. | Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner. | 2013 | Stem Cells Dev. | pmid:22873791 |
Liu Y et al. | Expression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development. | 2013 | PLoS ONE | pmid:24223801 |
Sachweh MC et al. | Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression. | 2013 | Cell Death Dis | pmid:23470540 |
Hudson RS et al. | Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. | 2013 | Mol. Cancer | pmid:23409773 |
Camolotto SA et al. | PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. | 2013 | PLoS ONE | pmid:23418492 |
Zutz C et al. | Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus. | 2013 | Toxins (Basel) | pmid:24105402 |
Viñuelas J et al. | Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts. | 2013 | BMC Biol. | pmid:23442824 |
Kim TW et al. | Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. | 2013 | BMC Cancer | pmid:24160266 |
Chachadi VB et al. | Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a. | 2013 | PLoS ONE | pmid:23451223 |
Kim YJ et al. | HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade. | 2013 | Oncogene | pmid:23435418 |
Moreaux J et al. | Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors. | 2013 | Br. J. Cancer | pmid:23868005 |
Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |
Singh RK et al. | Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a. | 2013 | Biochemistry | pmid:24079912 |
Day JA and Cohen SM | Investigating the selectivity of metalloenzyme inhibitors. | 2013 | J. Med. Chem. | pmid:24074025 |
Yan G et al. | Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells. | 2013 | Mol. Carcinog. | pmid:22290509 |
Okada T et al. | Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas. | 2013 | Cancer Sci. | pmid:23829175 |
Cong P et al. | Effects of trichostatin A on histone acetylation and methylation characteristics in early porcine embryos after somatic cell nuclear transfer. | 2013 | Anim. Sci. J. | pmid:23607426 |
Munro SK et al. | Histone deacetylase inhibition by trichostatin A mitigates LPS induced TNFα and IL-10 production in human placental explants. | 2013 | Placenta | pmid:23623485 |
Hayakawa K et al. | Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. | 2013 | J. Biol. Chem. | pmid:23625921 |
Neumann F et al. | EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors. | 2013 | Cancer Immunol. Immunother. | pmid:23619976 |
Yang H et al. | Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. | 2013 | Biochem. Pharmacol. | pmid:23643933 |
Majumder A et al. | Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors. | 2013 | Stem Cell Res | pmid:23644509 |
Arbuckle JH et al. | Mapping the telomere integrated genome of human herpesvirus 6A and 6B. | 2013 | Virology | pmid:23648233 |
Di Micco S et al. | Structural basis for the design and synthesis of selective HDAC inhibitors. | 2013 | Bioorg. Med. Chem. | pmid:23693069 |
Xia X et al. | Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. | 2013 | Transplantation | pmid:23694951 |
Fan J et al. | Inhibition of HDAC2 protects the retina from ischemic injury. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23696608 |
Li M et al. | Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23680675 |
Zhang Z et al. | Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells. | 2013 | Cell Death Dis | pmid:23681228 |
Kannan V et al. | Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. | 2013 | J. Neurosci. Res. | pmid:23686642 |
Oleksiewicz U et al. | Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. | 2013 | Hum. Mol. Genet. | pmid:23591990 |
Shi H et al. | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23201405 |
Hutz JE et al. | The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens. | 2013 | J Biomol Screen | pmid:23204073 |
Nakazawa Y et al. | Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes. | 2013 | J. Immunother. | pmid:23211626 |
Tavakoli-Yaraki M et al. | Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. | 2013 | Tumour Biol. | pmid:23055198 |
Koch M et al. | Overcoming chemotherapy resistance of ovarian cancer cells by liposomal cisplatin: molecular mechanisms unveiled by gene expression profiling. | 2013 | Biochem. Pharmacol. | pmid:23396090 |
Iwashita J et al. | Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes. | 2013 | Dev. Growth Differ. | pmid:23346879 |
Ji Q et al. | Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. | 2013 | Theriogenology | pmid:23347745 |
Theisen JW et al. | Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. | 2013 | J. Biol. Chem. | pmid:23349465 |
Nunes MJ et al. | Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. | 2013 | PLoS ONE | pmid:23326422 |
Murko C et al. | Histone deacetylase inhibitor Trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. | 2013 | Differentiation | pmid:23328540 |
Algamas-Dimantov A et al. | Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. | 2013 | Cell Oncol (Dordr) | pmid:23307400 |
Johnson D and Walmsley R | Histone-deacetylase inhibitors produce positive results in the GADD45a-GFP GreenScreen HC assay. | 2013 | Mutat. Res. | pmid:23340162 |
Zhou G et al. | HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23341636 |
Chan ST et al. | Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. | 2013 | PLoS ONE | pmid:23342112 |