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The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination. |
2008 |
Plant Physiol. |
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Small molecule regulators of autophagy identified by an image-based high-throughput screen. |
2007 |
Proc. Natl. Acad. Sci. U.S.A. |
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Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. |
2007 |
J. Gen. Virol. |
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Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. |
2007 |
Mol. Cancer Ther. |
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DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. |
2008 |
Hum. Mol. Genet. |
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Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos. |
2007 |
Reproduction |
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In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. |
2008 Mar-Apr |
J. Androl. |
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Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. |
2008 |
Cancer Immunol. Immunother. |
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Mazières J et al. |
Epigenetic regulation of RhoB loss of expression in lung cancer. |
2007 |
BMC Cancer |
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[Biological diversity of protein lysine acetylation which has been revealed by small molecule inhibitors]. |
2007 |
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2007 |
Tanpakushitsu Kakusan Koso |
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Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. |
2008 Sep-Oct |
J. Cell. Mol. Med. |
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Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). |
2008 |
Bioorg. Med. Chem. |
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Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. |
2007 |
Cancer Res. |
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Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. |
2007 |
Ann. N. Y. Acad. Sci. |
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Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. |
2007 |
Biochem. Cell Biol. |
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Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation, and its application to antibody engineering. |
2007 |
Biotechnol. Genet. Eng. Rev. |
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Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. |
2008 |
Breast Cancer Res. Treat. |
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Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines. |
2007 |
World J. Gastroenterol. |
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Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. |
2008 |
Oncogene |
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Walton TJ et al. |
DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. |
2008 |
Prostate |
pmid:18092350
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Arany I et al. |
Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. |
2008 |
Am. J. Physiol. Renal Physiol. |
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Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. |
2008 |
J. Immunol. |
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Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. |
2008 |
Int. J. Oncol. |
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Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone deacetylase inhibitor, Trichostatin A. |
2008 |
Oncol. Rep. |
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Yeh JR et al. |
AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. |
2008 |
Development |
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Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking. |
2008 |
Hepatology |
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Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. |
2007 |
Chin. Med. J. |
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Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells. |
2008 |
Cancer Res. |
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Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica. |
2008 |
Mol. Biochem. Parasitol. |
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Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. |
2008 |
Stem Cells |
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Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. |
2008 |
Leuk. Res. |
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The efficacy of combination therapy using adeno-associated virus--interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. |
2008 |
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Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. |
2008 |
FEBS Lett. |
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Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells. |
2008 |
Cell Prolif. |
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Potent antimalarial activity of histone deacetylase inhibitor analogues. |
2008 |
Antimicrob. Agents Chemother. |
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p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. |
2008 |
Oncogene |
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ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells. |
2007 Nov-Dec |
Anticancer Res. |
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The histone deacetylase inhibitor butyrate inhibits melanoma cell invasion of Matrigel. |
2007 Nov-Dec |
Anticancer Res. |
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Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. |
2008 |
Osteoarthr. Cartil. |
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Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. |
2008 |
Mol. Ther. |
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Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. |
2008 |
Exp. Neurol. |
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Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. |
2008 |
Circ. Res. |
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The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis. |
2008 |
Cell Cycle |
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The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. |
2008 |
Cloning Stem Cells |
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Trichostatin A and nuclear reprogramming of cloned rabbit embryos. |
2008 |
J. Anim. Sci. |
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Histone deacetylase inhibitors: from bench to clinic. |
2008 |
J. Med. Chem. |
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HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. |
2008 |
J. Biol. Chem. |
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Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? |
2007 |
Cancer Biol. Ther. |
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BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells. |
2008 |
FEBS Lett. |
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ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. |
2008 |
J. Cancer Res. Clin. Oncol. |
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Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. |
2008 |
Dev. Dyn. |
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Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera. |
2008 |
Cancer Sci. |
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CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. |
2008 |
J. Cell. Biochem. |
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Effect of histone deacetylase inhibitor trichostatin A (TSA) on the microtubular system of Tetrahymena. |
2007 |
Acta. Biol. Hung. |
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Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. |
2008 |
Exp. Mol. Pathol. |
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Nakamura C et al. |
Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. |
2008 |
Rheumatology (Oxford) |
pmid:18281366
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Schuetz A et al. |
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. |
2008 |
J. Biol. Chem. |
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Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts. |
2008 |
Exp. Eye Res. |
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Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. |
2008 |
Genes Cells |
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Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90. |
2008 |
Neurochem. Res. |
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Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes. |
2008 |
J. Exp. Biol. |
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Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents. |
2008 |
J. Pharmacol. Exp. Ther. |
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Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. |
2008 |
Mol. Cancer Res. |
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Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. |
2008 |
Genes Dev. |
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Fleury L et al. |
Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. |
2008 |
Oncogene |
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APE1/Ref-1 regulates PTEN expression mediated by Egr-1. |
2008 |
Free Radic. Res. |
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Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors. |
2008 |
J. Virol. |
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Borghol N et al. |
Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes. |
2008 |
Genomics |
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Balakrishnan L and Milavetz B |
HDAC inhibitors stimulate viral transcription by multiple mechanisms. |
2008 |
Virol. J. |
pmid:18353181
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Kimata Y et al. |
Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. |
2008 |
J. Cell. Sci. |
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Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes. |
2008 |
Toxicol. Lett. |
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[Effect of trichostatin A on proliferation and interleukin-2 expression of mouse T cells in mixed lymphocyte culture]. |
2008 |
Nan Fang Yi Ke Da Xue Xue Bao |
pmid:18359716
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Svechnikova I et al. |
HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. |
2008 |
Int. J. Oncol. |
pmid:18360709
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Mukherjee P et al. |
Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. |
2008 |
Bioorg. Med. Chem. |
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Brown SL et al. |
Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. |
2008 |
Radiat. Res. |
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Vrbova G |
Spinal muscular atrophy: motoneurone or muscle disease? |
2008 |
Neuromuscul. Disord. |
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SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. |
2008 |
PLoS Genet. |
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Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells. |
2008 |
Mol. Pharmacol. |
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The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage. |
2008 |
BMB Rep |
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Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. |
2008 |
Cancer Res. |
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Brain chromatin remodeling: a novel mechanism of alcoholism. |
2008 |
J. Neurosci. |
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Rebbaa A et al. |
Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent. |
2008 |
Angiogenesis |
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Liu TC et al. |
Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. |
2008 |
Mol. Ther. |
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Karantzali E et al. |
Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis. |
2008 |
Genome Biol. |
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Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. |
2008 |
Eur. J. Cell Biol. |
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[Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. |
2007 |
Zhonghua Zhong Liu Za Zhi |
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Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. |
2008 |
Bioorg. Med. Chem. Lett. |
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Chen PC et al. |
Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group. |
2008 |
Bioorg. Med. Chem. |
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Comparative molecular dynamics simulations of histone deacetylase-like protein: binding modes and free energy analysis to hydroxamic acid inhibitors. |
2008 |
Proteins |
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Ko JM et al. |
Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. |
2008 |
Mol. Cancer Res. |
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Histone deacetylase 5 represses the transcription of cyclin D3. |
2008 |
J. Cell. Biochem. |
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Kawamoto K et al. |
DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines. |
2008 |
Int. J. Cancer |
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Kaipparettu BA et al. |
Estrogen-mediated downregulation of CD24 in breast cancer cells. |
2008 |
Int. J. Cancer |
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Jeseta M et al. |
In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A. |
2008 |
Zygote |
pmid:18405435
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Iager AE et al. |
Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos. |
2008 |
Cloning Stem Cells |
pmid:18419249
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Habold C et al. |
Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. |
2008 |
J. Cell. Mol. Med. |
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Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. |
2008 |
Am. J. Respir. Cell Mol. Biol. |
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Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. |
2008 |
J. Immunol. |
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Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. |
2008 |
Bioorg. Med. Chem. Lett. |
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