trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang W et al. | Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. | 2005 | J. Biol. Chem. | pmid:15647279 |
| Choi JH et al. | Trichostatin A attenuates airway inflammation in mouse asthma model. | 2005 | Clin. Exp. Allergy | pmid:15649272 |
| Varshochi R et al. | ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. | 2005 | J. Biol. Chem. | pmid:15557281 |
| Goeman F et al. | Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. | 2005 | Mol. Cell. Biol. | pmid:15601862 |
| Tai HH et al. | Dynamic histone acetylation of late embryonic genes during seed germination. | 2005 | Plant Mol. Biol. | pmid:16307366 |
| Noh EJ et al. | Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells. | 2005 | Cancer Res. | pmid:16357148 |
| Wetzel M et al. | Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis. | 2005 | J. Neurosurg. | pmid:16383255 |
| Place RF et al. | HDACs and the senescent phenotype of WI-38 cells. | 2005 | BMC Cell Biol. | pmid:16250917 |
| Lee JH et al. | Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1. | 2005 | J. Endocrinol. | pmid:16293776 |
| Hazzalin CA and Mahadevan LC | Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. | 2005 | PLoS Biol. | pmid:16262446 |
| Hohl M and Thiel G | Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. | 2005 | Eur. J. Neurosci. | pmid:16262660 |
| Bernes S et al. | Epigenetic and classical activation of Entamoeba histolytica heat shock protein 100 (EHsp100) expression. | 2005 | FEBS Lett. | pmid:16263115 |
| Gao S et al. | CpG methylation of the PAI-1 gene 5'-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines. | 2005 | Thromb. Haemost. | pmid:16268485 |
| Li XX et al. | Function of c-Fos-like and c-Jun-like proteins on trichostatin A-induced G2/M arrest in Physarum polycephalum. | 2005 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:16270156 |
| Francia G et al. | Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents. | 2005 | Mol. Cancer Ther. | pmid:16227397 |
| Chou SD et al. | Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells. | 2005 | Int. Immunol. | pmid:16210330 |
| Bai Y et al. | Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. | 2005 | J. Immunol. | pmid:16210620 |
| Chen G et al. | [Enhancive effect of histone deacetylase inhibitor trichostatin a on transfection efficiency of adenovirus in ovarian carcinoma cell line A2780]. | 2005 | Ai Zheng | pmid:16219132 |
| Kasper LH et al. | Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. | 2005 | EMBO J. | pmid:16237459 |
| Columbaro M et al. | Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. | 2005 | Cell. Mol. Life Sci. | pmid:16261260 |
| Osada H et al. | Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. | 2005 | Mol. Carcinog. | pmid:16163707 |
| Rogier E et al. | A novel biological assay to detect the active form of TGF-beta in urine to monitor renal allograft rejection. | 2005 | Kidney Int. | pmid:16164666 |
| Di-Poï N et al. | Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. | 2005 | J. Biol. Chem. | pmid:16166081 |
| Spengler ML et al. | Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism. | 2005 | Cell. Signal. | pmid:15494207 |
| Valenzuela-Fernández A et al. | Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. | 2005 | Mol. Biol. Cell | pmid:16148047 |
| Davis FJ et al. | Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15388503 |
| Curtin BF et al. | Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. | 2005 | J. Cell. Biochem. | pmid:16149071 |
| Chen JS and Faller DV | Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. | 2005 | J. Cell. Physiol. | pmid:15389542 |
| Medugno L et al. | The Krüppel-like zinc-finger protein ZNF224 represses aldolase A gene transcription by interacting with the KAP-1 co-repressor protein. | 2005 | Gene | pmid:16150558 |
| Frønsdal K and Saatcioglu F | Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. | 2005 | Prostate | pmid:15389787 |
| Johnson J et al. | Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid. | 2005 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:16171558 |
| Karagiannis TC et al. | The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X. | 2005 | Cancer Biol. Ther. | pmid:16082178 |
| Xiong Y et al. | Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. | 2005 | Gynecol. Oncol. | pmid:16024066 |
| Fandy TE et al. | Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. | 2005 | Neoplasia | pmid:16026644 |
| Korutla L et al. | The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. | 2005 | J. Neurochem. | pmid:16033423 |
| Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
| Kemp MG et al. | The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. | 2005 | Nucleic Acids Res. | pmid:15653633 |
| Huang H et al. | MEIS C termini harbor transcriptional activation domains that respond to cell signaling. | 2005 | J. Biol. Chem. | pmid:15654074 |
| Danam RP et al. | Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. | 2005 | Mol. Cancer Ther. | pmid:15657354 |
| Li Y et al. | Histone deacetylation is required for progression through mitosis in tobacco cells. | 2005 | Plant J. | pmid:15659094 |
| Zhao Y et al. | Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. | 2005 | J. Exp. Biol. | pmid:15695762 |
| Hooven LA et al. | Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713371 |
| Chen B et al. | Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713393 |
| Duan H et al. | Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. | 2005 | Mol. Cell. Biol. | pmid:15713621 |
| Tong X et al. | Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. | 2005 | J. Biol. Chem. | pmid:15713675 |
| Gan Y et al. | Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. | 2005 | J. Biol. Chem. | pmid:15722551 |
| Endo M et al. | Novel gender-related regulation of CYP2C12 gene expression in rats. | 2005 | Mol. Endocrinol. | pmid:15661834 |
| Choi KH et al. | Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine. | 2005 | Glycoconj. J. | pmid:15864436 |
| Touma SE et al. | Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. | 2005 | Clin. Cancer Res. | pmid:15867260 |
| Fish JE et al. | The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. | 2005 | J. Biol. Chem. | pmid:15870070 |
| Dyson MH et al. | MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. | 2005 | J. Cell. Sci. | pmid:15870105 |
| Reid G et al. | Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. | 2005 | Oncogene | pmid:15870696 |
| Kim MS et al. | Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). | 2005 | Exp. Cell Res. | pmid:15878336 |
| Rosenqvist N et al. | Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain. | 2005 | Cell Transplant | pmid:15881422 |
| Gonçalves J et al. | Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells. | 2005 | Clin. Chem. Lab. Med. | pmid:15843208 |
| Robbins AR et al. | Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin. | 2005 | Cell Cycle | pmid:15846093 |
| Taghiyev AF et al. | Trichostatin A (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment. | 2005 | Cancer Biol. Ther. | pmid:15846101 |
| Barki-Celli L et al. | Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements. | 2005 | Genes Chromosomes Cancer | pmid:15846776 |
| Law RD and Suttle JC | Chromatin remodeling in plant cell culture: patterns of DNA methylation and histone H3 and H4 acetylation vary during growth of asynchronous potato cell suspensions. | 2005 | Plant Physiol. Biochem. | pmid:15922608 |
| Seo H et al. | Rapid generation of specific antibodies by enhanced homologous recombination. | 2005 | Nat. Biotechnol. | pmid:15924134 |
| Whang YM et al. | Hyperacetylation enhances the growth-inhibitory effect of all-trans retinoic acid by the restoration of retinoic acid receptor beta expression in head and neck squamous carcinoma (HNSCC) cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15959780 |
| Gunin AG et al. | Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. | 2005 | J. Endocrinol. | pmid:15930180 |
| Wittich S et al. | Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. | 2005 | Anticancer Drugs | pmid:15930892 |
| Kaneda R et al. | Genome-wide screening for target regions of histone deacetylases in cardiomyocytes. | 2005 | Circ. Res. | pmid:16002748 |
| Kusy S et al. | Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. | 2005 | Biochim. Biophys. Acta | pmid:16005989 |
| Rho JH et al. | Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. | 2005 | Int. J. Oncol. | pmid:16010429 |
| Choi YH | Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. | 2005 | Int. J. Oncol. | pmid:16010430 |
| Taddei A et al. | The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? | 2005 | EMBO Rep. | pmid:15940285 |
| Gray SG et al. | Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. | 2005 | J. Biol. Chem. | pmid:15927959 |
| Fishel ML et al. | Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15304523 |
| Kawamura T et al. | Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. | 2005 | J. Biol. Chem. | pmid:15764815 |
| Xiong Y et al. | Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. | 2005 | Cancer Res. | pmid:15805266 |
| Kumakura S et al. | Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. | 2005 | Cancer Res. | pmid:15805278 |
| Zhao W et al. | The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. | 2005 | J. Biochem. | pmid:15809347 |
| Subramanian C et al. | Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15778293 |
| Lu ZP et al. | Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15781251 |
| Nishigaki M et al. | Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. | 2005 | Cancer Res. | pmid:15781621 |
| Bai J et al. | Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. | 2005 | Cancer Res. | pmid:15781649 |
| Rahmani M et al. | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. | 2005 | Cancer Res. | pmid:15781658 |
| Frescas D et al. | Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. | 2005 | J. Biol. Chem. | pmid:15788402 |
| Kang J et al. | Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. | 2005 | Biochem. Pharmacol. | pmid:15794941 |
| Narayanan R et al. | Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. | 2005 | Mol. Cell. Biol. | pmid:15798179 |
| Koh SH et al. | Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15752760 |
| Bottardi S et al. | Onset and inheritance of abnormal epigenetic regulation in hematopoietic cells. | 2005 | Hum. Mol. Genet. | pmid:15615768 |
| Ezzat S et al. | The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. | 2005 | Mol. Endocrinol. | pmid:15618287 |
| Cecconi D et al. | Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335935 |
| Garcia BA et al. | Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335948 |
| Fan J et al. | [Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:17533736 |
| Li Y et al. | A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. | 2006 | Genes Dev. | pmid:16980585 |
| Minetti GC et al. | Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. | 2006 | Nat. Med. | pmid:16980968 |
| Yang QC et al. | Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. | 2006 | J. Exp. Clin. Cancer Res. | pmid:17310851 |
| Hernandez M et al. | A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. | 2006 | Prostate | pmid:16652385 |
| Uchida H et al. | Human endometrial cytodifferentiation by histone deacetylase inhibitors. | 2006 | Hum. Cell | pmid:16643606 |
| Li GC et al. | Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. | 2006 | Int. J. Urol. | pmid:16771729 |
| Sestáková B and Vachtenheim J | Distinct co-regulation of endogenous versus transfected MITF-dependent tyrosinase promoter. | 2006 | Folia Biol. (Praha) | pmid:17116288 |
| Liu H et al. | Trichostatin A regulates hGCN5 expression and cell cycle on Daudi cells in vitro. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219960 |
| Sun C et al. | Anticancer activities of trichostatin A on maligant lymphoid cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219961 |
| Villanueva R et al. | Histone deacetylase 3 represses HTLV-1 tax transcription. | 2006 | Oncol. Rep. | pmid:16865259 |
| van den Boom J et al. | Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. | 2006 | Int. J. Cancer | pmid:16865689 |
| Araki H et al. | Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. | 2006 | Exp. Hematol. | pmid:16459182 |