Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dangond F and Gullans SR | Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647779 |
Takamatsu G et al. | Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27939885 |
Tong X et al. | Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15063780 |
Choy SW et al. | C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17506990 |
Kitamoto S et al. | Promoter hypomethylation contributes to the expression of MUC3A in cancer cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20510874 |
Cowell RM et al. | Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19118529 |
Zampetaki A et al. | TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16814255 |
Togi S et al. | HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19121623 |
Nagaraja SS et al. | Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549Â cells. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28993195 |
Yamamura A et al. | Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24134849 |
Hu JF et al. | The role of histone acetylation in the allelic expression of the imprinted human insulin-like growth factor II gene. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792787 |
Herr MJ et al. | Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24747564 |
Lopatina NG et al. | Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12810068 |
Hasegawa T et al. | Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10066455 |
Inokoshi J et al. | Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079191 |
Bai J et al. | Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904634 |
Liu J and Li Y | Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26436206 |
Hara D et al. | Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19818730 |
Tan HH and Porter AG | p21(WAF1) negatively regulates DNMT1 expression in mammalian cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19275888 |
Gan Y et al. | Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:17996726 |