Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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McBlane F and Boyes J | Stimulation of V(D)J recombination by histone acetylation. | 2000 | Curr. Biol. | pmid:10801420 |
Hobbs CA and Gilmour SK | High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. | 2000 | J. Cell. Biochem. | pmid:10760944 |
Yoshida M and Horinouchi S | [Histone deacetylase inhibitors--new anticancer agents?]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10771678 |
Yu F et al. | Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. | 2000 | Nucleic Acids Res. | pmid:10773092 |
Kitamura K et al. | Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. | 2000 | Br. J. Haematol. | pmid:10792271 |
Saleh M et al. | Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. | 2000 | Mol. Cell. Biol. | pmid:11046157 |
Diamond SE and Gutierrez-Hartmann A | The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. | 2000 | J. Biol. Chem. | pmid:10921928 |
Andoh A et al. | Modulation of complement component (C3 and factor B) biosynthesis by a histone deacetylase inhibitor in human intestinal epithelial cells. | 2000 | Int. J. Mol. Med. | pmid:10851266 |
Siavoshian S et al. | Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. | 2000 | Gut | pmid:10716680 |
Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
Mao C and Shapiro DJ | A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. | 2000 | Endocrinology | pmid:10875235 |
Clayton AL et al. | Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. | 2000 | EMBO J. | pmid:10899125 |
Kang J et al. | Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. | 2000 | J. Biol. Chem. | pmid:10913161 |
Yu J et al. | Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. | 2000 | Mol. Cell. Biol. | pmid:10713181 |
Shin JY et al. | Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. | 2000 | Cancer Res. | pmid:10667572 |
Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
Garrison PM et al. | Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. | 2000 | Arch. Biochem. Biophys. | pmid:10666294 |
Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
Kim YB et al. | Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. | 2000 | J. Antibiot. | pmid:11132966 |
Fukuda K | Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224675 |
Schmidt K et al. | Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. | 1999 | Arch. Pharm. (Weinheim) | pmid:10575368 |
Jung M et al. | Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. | 1999 | J. Med. Chem. | pmid:10579829 |
Chien PY et al. | A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells. | 1999 | Mol. Endocrinol. | pmid:10598586 |
Taddei A et al. | Duplication and maintenance of heterochromatin domains. | 1999 | J. Cell Biol. | pmid:10601331 |
Yoshida M and Horinouchi S | Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667200 |
Sowa Y et al. | Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667218 |
Kim YB et al. | Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667219 |
Marenzi S et al. | Efficiency of expression of transfected genes depends on the cell cycle. | 1999 | Mol. Biol. Rep. | pmid:10634509 |
Gray SG et al. | IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells. | 1999 | Exp. Cell Res. | pmid:10585285 |
Bakin AV and Curran T | Role of DNA 5-methylcytosine transferase in cell transformation by fos. | 1999 | Science | pmid:9888853 |
Verdel A and Khochbin S | Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. | 1999 | J. Biol. Chem. | pmid:9891014 |
Coffee B et al. | Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. | 1999 | Nat. Genet. | pmid:10319871 |
Xiao H et al. | Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells. | 1999 | J. Cell. Biochem. | pmid:10321829 |
Mielnicki LM et al. | Epigenetic regulation of gelsolin expression in human breast cancer cells. | 1999 | Exp. Cell Res. | pmid:10328963 |
Krajewski WA | Effect of in vivo histone hyperacetylation on the state of chromatin fibers. | 1999 | J. Biomol. Struct. Dyn. | pmid:10333179 |
Yoshida M | [Discovery of cell cycle inhibitors and their application to molecular biology]. | 1999 | Jpn J Antibiot | pmid:10221182 |
Feng YQ et al. | Enhancer-dependent transcriptional oscillations in mouse erythroleukemia cells. | 1999 | Mol. Cell. Biol. | pmid:10373540 |
Gobl AE et al. | Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. | 1999 | Biochim. Biophys. Acta | pmid:10500243 |
Kosugi H et al. | Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy. | 1999 | Leukemia | pmid:10482980 |
Carmen AA et al. | Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10535926 |
Rüller S et al. | Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. | 1999 | Clin. Cancer Res. | pmid:10537334 |
Vanden Berghe W et al. | The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. | 1999 | J. Biol. Chem. | pmid:10542243 |
Ng HH et al. | MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. | 1999 | Nat. Genet. | pmid:10471499 |
Sowa Y et al. | Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. | 1999 | Cancer Res. | pmid:10485470 |
Finnin MS et al. | Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. | 1999 | Nature | pmid:10490031 |
Huang Y et al. | Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. | 1999 | Nat. Neurosci. | pmid:10491605 |
List HJ et al. | Inhibition of histone deacetylation augments dihydrotestosterone induction of androgen receptor levels: an explanation for trichostatin A effects on androgen-induced chromatin remodeling and transcription of the mouse mammary tumor virus promoter. | 1999 | Exp. Cell Res. | pmid:10527637 |
Bordonaro M et al. | Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin. | 1999 | Cell Growth Differ. | pmid:10547075 |
KraevskiÄ VA and Prasolov VS | [Comparative analysis of higher levels of organization of normal and hyperacetylated chromatin]. | 1999 | Dokl. Akad. Nauk. | pmid:10439916 |