Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Oliveira CS et al. | Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos. | 2010 | Reprod. Fertil. Dev. | pmid:20591338 |
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Xia J et al. | Epigenetic modification of vomeronasal (V2r) precursor neurons by histone deacetylation. | 2010 | Neuroscience | pmid:20594945 |
Tian F et al. | Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons. | 2010 | Ann. N. Y. Acad. Sci. | pmid:20633124 |
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Beedanagari SR et al. | Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. | 2010 | Toxicol. Lett. | pmid:20116417 |
Lu Y et al. | Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. | 2010 | Hum. Reprod. | pmid:20118114 |
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Hajji N et al. | Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. | 2010 | Oncogene | pmid:20118981 |
Suh HS et al. | Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. | 2010 | J Neuroimmune Pharmacol | pmid:20157787 |
Crosson CE et al. | Inhibition of histone deacetylase protects the retina from ischemic injury. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20164449 |
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Desai D et al. | SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20167479 |
Ishimaru N et al. | Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20188708 |
Popova AP et al. | Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20190033 |
Calonge TM et al. | Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1. | 2010 | Genetics | pmid:20194963 |
Fakhry H et al. | Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells. | 2010 | Hum. Pathol. | pmid:20178884 |
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Aizawa S and Yamamuro Y | Involvement of histone acetylation in the regulation of choline acetyltransferase gene in NG108-15 neuronal cells. | 2010 | Neurochem. Int. | pmid:20100532 |
Tamannai M et al. | The inhibitor of growth 1 (ING1) is involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells. | 2010 | Oncol. Res. | pmid:20681406 |
Wu J et al. | Trichostatin A sensitizes cisplatin-resistant A549 cells to apoptosis by up-regulating death-associated protein kinase. | 2010 | Acta Pharmacol. Sin. | pmid:20048748 |
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Hebbel RP et al. | The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. | 2010 | Blood | pmid:20053759 |
Fu J et al. | Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase. | 2010 | Bioorg. Med. Chem. | pmid:21067930 |
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Nicodeme E et al. | Suppression of inflammation by a synthetic histone mimic. | 2010 | Nature | pmid:21068722 |
Ajiro K et al. | Reciprocal epigenetic modification of histone H2B occurs in chromatin during apoptosis in vitro and in vivo. | 2010 | Cell Death Differ. | pmid:20057502 |
Auzzas L et al. | Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. | 2010 | J. Med. Chem. | pmid:21073160 |
Choi YS et al. | Differentiation of human adipose-derived stem cells into beating cardiomyocytes. | 2010 | J. Cell. Mol. Med. | pmid:20070436 |
Lee KJ et al. | Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. | 2010 | Biochim. Biophys. Acta | pmid:20080132 |
Grabiec AM et al. | Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. | 2010 | J. Immunol. | pmid:20100935 |
Chatterjee A et al. | An efficient synthesis of (+/-)-trichostatic Acid and analogues: a new route to (+/-)-trichostatin A. | 2010 | Org. Lett. | pmid:20104892 |
Kicic A et al. | Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20110557 |
Su Y et al. | Human RecQL4 helicase plays critical roles in prostate carcinogenesis. | 2010 | Cancer Res. | pmid:21045146 |
Taura A et al. | Histone deacetylase inhibition enhances adenoviral vector transduction in inner ear tissue. | 2010 | Neuroscience | pmid:20060033 |
Chou JL et al. | Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer. | 2010 | Lab. Invest. | pmid:20065949 |
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Chang J et al. | Hepatopoietin Cn suppresses apoptosis of human hepatocellular carcinoma cells by up-regulating myeloid cell leukemia-1. | 2010 | World J. Gastroenterol. | pmid:20066738 |
Li Y et al. | Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. | 2010 | Mol. Cancer | pmid:20946668 |
Gupta PK et al. | Inhibitors selective for HDAC6 in enzymes and cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20947351 |
Song S et al. | Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1. | 2010 | Cardiovasc. Res. | pmid:19633316 |
Eskeland R et al. | Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes. | 2010 | Cold Spring Harb. Symp. Quant. Biol. | pmid:21502416 |
Shiau RJ et al. | Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. | 2010 | Eur J Nutr | pmid:19639378 |
Chao KC et al. | Anti-tumor activity of histone deacetylase inhibitors and the effect on ATP-binding cassette in ovarian carcinoma cells. | 2010 | Eur. J. Gynaecol. Oncol. | pmid:20882882 |
Lee CS et al. | 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. | 2010 | Eur. J. Pharmacol. | pmid:20868669 |
Yuan GB et al. | Combined effects of all-trans-retinoic acid and trichostatin A on the induction of differentiation of thyroid carcinoma cells. | 2010 | Chin J Cancer | pmid:20346212 |
Wang QH et al. | Opposite effects of Trichostatin A on activation of mast cells by different stimulants. | 2010 | FEBS Lett. | pmid:20371366 |
Simboeck E et al. | A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors. | 2010 | J. Biol. Chem. | pmid:20952396 |
Robertson DM et al. | C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20375332 |
Halili MA et al. | Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. | 2010 | J. Leukoc. Biol. | pmid:20200406 |
Karagiannis TC et al. | Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes. | 2010 | Aging (Albany NY) | pmid:20930262 |
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Gao A et al. | Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression. | 2010 | Toxicol. Lett. | pmid:20230882 |
Majid S et al. | Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer. | 2010 | Cancer Res. | pmid:20332239 |
Khobta A et al. | Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. | 2010 | Nucleic Acids Res. | pmid:20338881 |
Kim SH et al. | Trichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein. | 2010 | Breast Cancer Res. | pmid:20388208 |
Kongruttanachok N et al. | Replication independent DNA double-strand break retention may prevent genomic instability. | 2010 | Mol. Cancer | pmid:20356374 |
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Choi JH et al. | TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19914212 |
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Bhuiyan MM et al. | Production of Sei whale (Balaenoptera borealis) cloned embryos by inter- and intra-species somatic cell nuclear transfer. | 2010 | J. Reprod. Dev. | pmid:19893277 |
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Higashiyama R et al. | Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. | 2010 | Mod Rheumatol | pmid:19784544 |
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Kobori A et al. | Butyrate stimulates IL-32alpha expression in human intestinal epithelial cell lines. | 2010 | World J. Gastroenterol. | pmid:20480520 |
Kiyokawa S et al. | New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group. | 2010 | Bioorg. Med. Chem. | pmid:20452226 |
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Zhao TC et al. | gp-91 mediates histone deacetylase inhibition-induced cardioprotection. | 2010 | Biochim. Biophys. Acta | pmid:20433879 |