Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen YX et al. | [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. | 2004 | Zhonghua Yi Xue Za Zhi | pmid:15059516 |
Wang CT and Meng M | [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17650409 |
Ji S et al. | [Association of irradiation-induced hippocampal neurogenesis impairment with histone H3 acetylation]. | 2015 | Zhonghua Yi Xue Za Zhi | pmid:26168675 |
Sun DF et al. | [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. | 2007 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:17680526 |
Zheng L et al. | [Detecting acetylated proteins by affinity chromatography column]. | 2012 | Zhonghua Xue Ye Xue Za Zhi | pmid:22781610 |
Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. | 2009 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:19742343 |
Li YL et al. | [Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. | 2007 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:17659468 |
Ju ZH et al. | [Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines]. | 2010 | Zhonghua Wai Ke Za Zhi | pmid:20450613 |
Wang H et al. | [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-α stimulation]. | 2016 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:27117217 |
Han JQ et al. | [Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18822204 |