trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Amin HM et al. | Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). | 2001 | Br. J. Haematol. | pmid:11703323 |
| Pile LA et al. | The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. | 2001 | Cell. Mol. Life Sci. | pmid:11706997 |
| Sachs LM et al. | An essential role of histone deacetylases in postembryonic organ transformations in Xenopus laevis. | 2001 | Int. J. Mol. Med. | pmid:11712071 |
| Lefevre P et al. | Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element. | 2001 | Nucleic Acids Res. | pmid:11713304 |
| Sekita N et al. | Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines. | 2001 | Jpn. J. Cancer Res. | pmid:11572762 |
| Yin L et al. | Butyrate suppression of colonocyte NF-kappa B activation and cellular proteasome activity. | 2001 | J. Biol. Chem. | pmid:11572859 |
| Leng SL et al. | Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo. | 2001 | Carcinogenesis | pmid:11577001 |
| Yang X et al. | Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. | 2001 | Cancer Res. | pmid:11585728 |
| Takakura M et al. | Telomerase activation by histone deacetylase inhibitor in normal cells. | 2001 | Nucleic Acids Res. | pmid:11452025 |
| Ferraro M et al. | Involvement of histone H4 acetylation in the epigenetic inheritance of different activity states of maternally and paternally derived genomes in the mealybug Planococcus citri. | 2001 | Chromosoma | pmid:11453559 |
| Marianna P et al. | Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. | 2001 | Haematologica | pmid:11454524 |
| Cho JH et al. | DNA methylation regulates placental lactogen I gene expression. | 2001 | Endocrinology | pmid:11459782 |
| Walker GE et al. | Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. | 2001 | Endocrinology | pmid:11517158 |
| Jorgensen JS and Nilson JH | AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. | 2001 | Mol. Endocrinol. | pmid:11518798 |
| Phiel CJ et al. | Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. | 2001 | J. Biol. Chem. | pmid:11473107 |
| Sundqvist A et al. | Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription. | 2001 | Exp. Cell Res. | pmid:11478854 |
| Jacob AL et al. | Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5. | 2001 | J. Biol. Chem. | pmid:11479297 |
| Lavelle D et al. | Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. | 2001 | Am. J. Hematol. | pmid:11754398 |
| Williams RJ | Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis. | 2001 | Expert Opin Investig Drugs | pmid:11785457 |
| Li J et al. | Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. | 2001 | Mol. Cell. Biol. | pmid:11689710 |
| Hirschler-Laszkiewicz I et al. | The role of acetylation in rDNA transcription. | 2001 | Nucleic Acids Res. | pmid:11600700 |
| Nair AR et al. | Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. | 2001 | Cancer Lett. | pmid:11295287 |
| Archer SY et al. | p21 gene regulation during enterocyte differentiation. | 2001 | J. Surg. Res. | pmid:11368530 |
| Ma J et al. | Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression. | 2001 | Biol. Reprod. | pmid:11369600 |
| Della Ragione F et al. | Genes modulated by histone acetylation as new effectors of butyrate activity. | 2001 | FEBS Lett. | pmid:11423116 |
| Maës J et al. | Chromatin remodeling at the Ig loci prior to V(D)J recombination. | 2001 | J. Immunol. | pmid:11441093 |
| Wang H et al. | Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. | 2001 | Science | pmid:11387442 |
| Klar AJ et al. | A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. | 2001 | Genetics | pmid:11404352 |
| Massa S et al. | 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. | 2001 | J. Med. Chem. | pmid:11405644 |
| Setlow JK et al. | Evidence for gene silencing in Haemophilus influenzae. | 2001 | Mutat. Res. | pmid:11406170 |
| Singal R et al. | Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells. | 2001 | Cancer Res. | pmid:11406558 |
| Baur JA et al. | Telomere position effect in human cells. | 2001 | Science | pmid:11408657 |
| Zelivianski S et al. | Multipathways for transdifferentiation of human prostate cancer cells into neuroendocrine-like phenotype. | 2001 | Biochim. Biophys. Acta | pmid:11389966 |
| Feng YQ et al. | Position effects are influenced by the orientation of a transgene with respect to flanking chromatin. | 2001 | Mol. Cell. Biol. | pmid:11113204 |
| Harada Y et al. | A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11396961 |
| Mehra-Chaudhary R et al. | Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. | 2001 | Biochem. J. | pmid:11115394 |
| Yang H et al. | Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11208539 |
| Kosugi H et al. | In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice. | 2001 | Jpn. J. Cancer Res. | pmid:11376562 |
| Wu JT et al. | Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11171632 |
| Taddei A et al. | Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. | 2001 | Nat. Cell Biol. | pmid:11175742 |
| Ferrara FF et al. | Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. | 2001 | Cancer Res. | pmid:11196162 |
| Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
| Johnson CA et al. | Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. | 2001 | J. Biol. Chem. | pmid:11136718 |
| Griswold MD et al. | Mechanisms involved in the homologous down-regulation of transcription of the follicle-stimulating hormone receptor gene in Sertoli cells. | 2001 | Mol. Cell. Endocrinol. | pmid:11223181 |
| Chang YC et al. | Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene. | 2001 | Mol. Cell. Biol. | pmid:11158299 |
| Newell-Price J et al. | The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression. | 2001 | Mol. Endocrinol. | pmid:11158338 |
| Bernhard D et al. | Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts. | 2001 | Cell Death Differ. | pmid:11598799 |
| Hatama S et al. | Isolation and sequencing of infectious clones of feline foamy virus and a human/feline foamy virus Env chimera. | 2001 | J. Gen. Virol. | pmid:11714976 |
| Yoshioka H et al. | A novel in vitro system for analyzing parental allele-specific histone acetylation in genomic imprinting. | 2001 | J. Hum. Genet. | pmid:11721881 |
| He LZ et al. | Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. | 2001 | J. Clin. Invest. | pmid:11696577 |