trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chawalit S et al. | Trichostatin A and ascorbic acid assist in the development of porcine handmade cloned embryos via different physiologic pathways. | 2012 | Reprod Sci | pmid:22534331 |
| Wang W et al. | The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. | 2012 | Nucleic Acids Res. | pmid:21967847 |
| Lee TB et al. | Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline. | 2012 | Cell Biol. Toxicol. | pmid:21968610 |
| Rhodes LV et al. | The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. | 2012 | Oncol. Rep. | pmid:21971930 |
| Liu W et al. | HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. | 2012 | PLoS ONE | pmid:23152903 |
| Hong X et al. | Heparanase expression is associated with histone modifications in glioblastoma. | 2012 | Int. J. Oncol. | pmid:22001963 |
| Yang G et al. | Trichostatin a promotes cardiomyocyte differentiation of rat mesenchymal stem cells after 5-azacytidine induction or during coculture with neonatal cardiomyocytes via a mechanism independent of histone deacetylase inhibition. | 2012 | Cell Transplant | pmid:21944777 |
| Kadaja-Saarepuu L et al. | Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. | 2012 | Int. J. Oncol. | pmid:21947346 |
| Ekici M et al. | Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: major regulatory role of REST and Sp1. | 2012 | J. Cell. Biochem. | pmid:21948504 |
| Rosborough BR et al. | Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. | 2012 | J. Leukoc. Biol. | pmid:22028329 |
| Ying H et al. | Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. | 2012 | PLoS ONE | pmid:23166597 |
| Tsuboi H et al. | Epigenetic memory of DNAi associated with cytosine methylation and histone modification in fern. | 2012 | Plant Signal Behav | pmid:22990449 |
| Maroni P et al. | Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23085045 |
| Lopez-Atalaya JP et al. | Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome. | 2012 | J. Med. Genet. | pmid:21984751 |
| Li Y et al. | Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. | 2012 | Cancer Lett. | pmid:22266186 |
| Bajbouj K et al. | P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. | 2012 | J. Neurooncol. | pmid:22270849 |
| Park KS et al. | Histone modification-mediated Lhx2 gene expression. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23036195 |
| Zhang L et al. | Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22271820 |
| He D et al. | Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma. | 2012 | Eur. J. Cancer Prev. | pmid:22273848 |
| Hosoya T et al. | Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. | 2012 | J. Nat. Prod. | pmid:22276693 |
| Baud MG et al. | Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. | 2012 | J. Med. Chem. | pmid:22280363 |
| Heller G et al. | Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers. | 2012 | Clin. Cancer Res. | pmid:22282464 |
| Hirata Y et al. | Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22321215 |
| Sawai K et al. | Epigenetic status and full-term development of bovine cloned embryos treated with trichostatin A. | 2012 | J. Reprod. Dev. | pmid:22322145 |
| Banerjee A et al. | Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22298527 |
| Kerr JB et al. | The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. | 2012 | Reproduction | pmid:22301887 |
| Li H et al. | Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. | 2012 | Diabetes | pmid:22338096 |
| Duncan HF et al. | Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. | 2012 | J Endod | pmid:22341071 |
| Kohda T et al. | Gene expression profile normalization in cloned mice by trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22257163 |
| Drzewiecka H and Jagodzinski PP | Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22257695 |
| Kan R et al. | Potential role for PADI-mediated histone citrullination in preimplantation development. | 2012 | BMC Dev. Biol. | pmid:22712504 |
| Mateen S et al. | Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells. | 2012 | Epigenetics | pmid:22965008 |
| To SQ et al. | Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22929011 |
| Liao V et al. | Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22932316 |
| Shan J et al. | ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. | 2012 | J. Biol. Chem. | pmid:22955275 |
| Sadoul K et al. | HDAC6 controls the kinetics of platelet activation. | 2012 | Blood | pmid:22955928 |
| de Souza CF et al. | Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. | 2012 | PLoS ONE | pmid:22984562 |
| Otsuji TG et al. | Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes. | 2012 | PLoS ONE | pmid:22984602 |
| Ma P et al. | Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22223663 |
| Szablowska-Gadomska I et al. | Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood. | 2012 | Acta Neurobiol Exp (Wars) | pmid:23377265 |
| Wang B et al. | Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage. | 2012 | Free Radic. Biol. Med. | pmid:22226832 |
| Liu H et al. | Inhibition of class II histone deacetylase blocks proliferation and promotes neuronal differentiation of the embryonic rat neural progenitor cells. | 2012 | Acta Neurobiol Exp (Wars) | pmid:23377267 |
| Barrasa JI et al. | Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. | 2012 | Biochim. Biophys. Acta | pmid:22227581 |
| Becker JR et al. | In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. | 2012 | Cardiovasc. Res. | pmid:22198505 |
| Hsu YF et al. | Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22155142 |
| Bebenek IG et al. | CYP2S1 is negatively regulated by corticosteroids in human cell lines. | 2012 | Toxicol. Lett. | pmid:22155357 |
| Sakuma Y et al. | WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. | 2012 | Lab. Invest. | pmid:22157722 |
| Schor IE et al. | Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. | 2012 | PLoS ONE | pmid:23152763 |
| Chang J et al. | Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. | 2012 | Br. J. Cancer | pmid:22158273 |
| Calfa G et al. | HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. | 2012 | Hippocampus | pmid:22161912 |
| Cheng SP et al. | Regulation of leptin receptor expression in human papillary thyroid cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22560341 |
| Sung TY et al. | Innovative in vitro chemo-hormonal drug therapy for refractory thyroid carcinomas. | 2012 | J. Korean Med. Sci. | pmid:22787366 |
| Agudelo M et al. | Alcohol-induced serotonergic modulation: the role of histone deacetylases. | 2012 | Alcohol | pmid:22796363 |
| Tong K et al. | Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. | 2012 | Eukaryotic Cell | pmid:22771823 |
| Zheng L et al. | [Detecting acetylated proteins by affinity chromatography column]. | 2012 | Zhonghua Xue Ye Xue Za Zhi | pmid:22781610 |
| Yao J et al. | ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism. | 2012 | Life Sci. | pmid:22781708 |
| Cheng DD et al. | Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799338 |
| Mostovich LA et al. | The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer. | 2012 | Epigenetics | pmid:22805760 |
| Kadowaki M et al. | DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. | 2012 | Int. J. Cancer | pmid:21437897 |
| Zou Y et al. | Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia. | 2012 | J Hematol Oncol | pmid:22747680 |
| Scholl C et al. | Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain. | 2012 | BMC Genomics | pmid:22748179 |
| Soleymani Fard S et al. | Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6). | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749740 |
| Brose RD et al. | Activation of the stress proteome as a mechanism for small molecule therapeutics. | 2012 | Hum. Mol. Genet. | pmid:22752410 |
| Jasek E et al. | Effect of histone deacetylase inhibitors trichostatin A and valproic acid on etoposide-induced apoptosis in leukemia cells. | 2012 | Anticancer Res. | pmid:22753739 |
| Gan L et al. | Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. | 2012 | PLoS ONE | pmid:22761896 |
| Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
| Gou Z et al. | Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens. | 2012 | PLoS ONE | pmid:22438967 |
| Bar-Nur O et al. | Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives. | 2012 | J Mol Cell Biol | pmid:22430918 |
| Hu XL et al. | [Effects of trichostatin A on the expressions of inflammatory cytokines and toll-like receptor 4 and the acetylation of nuclear factor-κB induced by lipopolysaccharide in macrophage]. | 2012 | Sheng Li Xue Bao | pmid:23258328 |
| Jung N et al. | Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma. | 2012 | J. Korean Med. Sci. | pmid:22690089 |
| Nunes MJ et al. | Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway. | 2012 | J. Lipid Res. | pmid:22693257 |
| Kim Y et al. | Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. | 2012 | J. Biol. Chem. | pmid:22679019 |
| Royce SG et al. | Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice. | 2012 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:22684086 |
| Zhang YW et al. | Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. | 2012 | PLoS ONE | pmid:22701735 |
| Mitchell MD et al. | Epigenetic regulation of cytokine production in human amnion and villous placenta. | 2012 | Mediators Inflamm. | pmid:22665947 |
| Buurman R et al. | Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. | 2012 | Gastroenterology | pmid:22641068 |
| Orlova DY et al. | Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. | 2012 | J. Cell. Biochem. | pmid:22644811 |
| Glait-Santar C et al. | Expression pattern of SVEP1 alternatively-spliced forms. | 2012 | Gene | pmid:22659106 |
| Xiong H et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. | 2012 | Mol. Carcinog. | pmid:21520296 |
| Park J et al. | ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22580278 |
| Yin Z et al. | Position effect variegation and epigenetic modification of a transgene in a pig model. | 2012 | Genet. Mol. Res. | pmid:22370938 |
| Zhu K et al. | Expression characterization and the promoter activity analysis of zebrafish hdac4. | 2012 | Fish Physiol. Biochem. | pmid:21773810 |
| Bence M et al. | Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. | 2012 | J Neural Transm | pmid:21785940 |
| Kraus J | Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22823387 |
| Qiao F et al. | Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells. | 2012 | Oncol. Rep. | pmid:22825043 |
| Shao G et al. | [Effect of monoamine oxidase inhibitor on the differentiation of malignant glioma cell]. | 2012 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:22826952 |
| Yu J et al. | Regulation of radiosensitivity by HDAC inhibitor trichostatin A in the human cervical carcinoma cell line Hela. | 2012 | Eur. J. Gynaecol. Oncol. | pmid:22873101 |
| Karolczak-Bayatti M et al. | Expression of the GTP-binding protein Gαs in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A. | 2012 | Reprod Sci | pmid:22875848 |
| Balaguer TM et al. | Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines. | 2012 | BMC Mol. Biol. | pmid:22846052 |
| Li L et al. | Regulation of histone acetylation by NDRG2 in glioma cells. | 2012 | J. Neurooncol. | pmid:21912936 |
| Yang F et al. | Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte. | 2012 | Int. J. Dev. Biol. | pmid:23417411 |
| Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
| Jee BC et al. | Effect of trichostatin A on fertilization and embryo development during extended culture of mouse oocyte. | 2012 | Zygote | pmid:21269543 |
| SustáÄková G et al. | Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. | 2012 | J. Cell. Physiol. | pmid:21732356 |
| Dehnugara T et al. | An in vitro, short-term culture method for mammalian haploid round spermatids amenable for molecular manipulation. | 2012 | Mol. Reprod. Dev. | pmid:21953649 |
| McCullough SD et al. | Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23236151 |
| Xie BT et al. | [Telomere lengthening by trichostatin A treatment in cloned pigs]. | 2012 | Yi Chuan | pmid:23262106 |
| He M and Guo Q | [Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22561570 |
| Catalano MG et al. | Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22563106 |
| Yu L et al. | Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis. | 2012 | Arch. Med. Res. | pmid:22564421 |