| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenomyosis | D062788 | 1 associated lipids |
| Neoplasm Micrometastasis | D061206 | 1 associated lipids |
| Visceral Pain | D059265 | 1 associated lipids |
| Inflammatory Breast Neoplasms | D058922 | 2 associated lipids |
| Capsule Opacification | D058442 | 1 associated lipids |
| Intervertebral Disc Degeneration | D055959 | 1 associated lipids |
| Small Cell Lung Carcinoma | D055752 | 2 associated lipids |
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Classical Lissencephalies and Subcortical Band Heterotopias | D054221 | 1 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Gestational Trophoblastic Disease | D031901 | 1 associated lipids |
| Carcinoma, Pancreatic Ductal | D021441 | 6 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Myopathy, Central Core | D020512 | 1 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Bone Marrow Neoplasms | D019046 | 2 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Neuroendocrine Tumors | D018358 | 4 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Cicatrix, Hypertrophic | D017439 | 4 associated lipids |
| Polycystic Kidney, Autosomal Dominant | D016891 | 6 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Leukemia, Myelomonocytic, Acute | D015479 | 6 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
| Kang FW et al. | Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. | 2012 | Oncol. Rep. | pmid:22552321 |
| Meng J et al. | The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. | 2012 | Oncol. Rep. | pmid:22552631 |
| Hsieh TH et al. | Phthalates stimulate the epithelial to mesenchymal transition through an HDAC6-dependent mechanism in human breast epithelial stem cells. | 2012 | Toxicol. Sci. | pmid:22552774 |
| Chawalit S et al. | Trichostatin A and ascorbic acid assist in the development of porcine handmade cloned embryos via different physiologic pathways. | 2012 | Reprod Sci | pmid:22534331 |
| Wang W et al. | The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. | 2012 | Nucleic Acids Res. | pmid:21967847 |
| Liu W et al. | HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. | 2012 | PLoS ONE | pmid:23152903 |
| Banik D et al. | Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. | 2012 | PLoS ONE | pmid:23028998 |
| Lopez-Atalaya JP et al. | Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome. | 2012 | J. Med. Genet. | pmid:21984751 |
| Bergman JA et al. | Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. | 2012 | J. Med. Chem. | pmid:23009203 |
| Li Y et al. | Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. | 2012 | Cancer Lett. | pmid:22266186 |
| Vaidya AS et al. | Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23010266 |
| Bajbouj K et al. | P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. | 2012 | J. Neurooncol. | pmid:22270849 |
| Park KS et al. | Histone modification-mediated Lhx2 gene expression. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23036195 |
| Zhang L et al. | Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22271820 |
| Kan R et al. | Potential role for PADI-mediated histone citrullination in preimplantation development. | 2012 | BMC Dev. Biol. | pmid:22712504 |
| Miyagawa K et al. | Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice. | 2012 | Behav. Brain Res. | pmid:22963996 |
| Liu N et al. | Histone deacetylase inhibitors inducing human cervical cancer cell apoptosis by decreasing DNA-methyltransferase 3B. | 2012 | Chin. Med. J. | pmid:22964322 |
| Brown RE et al. | Superinduction of leptin mRNA in mouse hypothalamic neurons. | 2012 | Neuroreport | pmid:22964970 |
| Mateen S et al. | Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells. | 2012 | Epigenetics | pmid:22965008 |
| To SQ et al. | Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22929011 |
| Liao V et al. | Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22932316 |
| Shan J et al. | ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. | 2012 | J. Biol. Chem. | pmid:22955275 |
| Conway GD et al. | Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation. | 2012 | Glia | pmid:22927334 |
| Cheng SP et al. | Regulation of leptin receptor expression in human papillary thyroid cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22560341 |
| He Q et al. | Characterization of an apical ceramide-enriched compartment regulating ciliogenesis. | 2012 | Mol. Biol. Cell | pmid:22718902 |
| Balmer NV et al. | Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. | 2012 | Hum. Mol. Genet. | pmid:22723015 |
| Oh HJ et al. | Trichostatin a improves preimplantation development of bovine cloned embryos and alters expression of epigenetic and pluripotency genes in cloned blastocysts. | 2012 | J. Vet. Med. Sci. | pmid:22785124 |
| Sung TY et al. | Innovative in vitro chemo-hormonal drug therapy for refractory thyroid carcinomas. | 2012 | J. Korean Med. Sci. | pmid:22787366 |
| Agudelo M et al. | Alcohol-induced serotonergic modulation: the role of histone deacetylases. | 2012 | Alcohol | pmid:22796363 |
| Tong K et al. | Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. | 2012 | Eukaryotic Cell | pmid:22771823 |
| Zheng L et al. | [Detecting acetylated proteins by affinity chromatography column]. | 2012 | Zhonghua Xue Ye Xue Za Zhi | pmid:22781610 |
| Kadowaki M et al. | DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. | 2012 | Int. J. Cancer | pmid:21437897 |
| Eun CH et al. | Activation and epigenetic regulation of DNA transposon nDart1 in rice. | 2012 | Plant Cell Physiol. | pmid:22514089 |
| Ching LY et al. | Synergistic effect of p53 on TSA-induced stanniocalcin 1 expression in human nasopharyngeal carcinoma cells, CNE2. | 2012 | J. Mol. Endocrinol. | pmid:22493143 |
| Gou Z et al. | Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens. | 2012 | PLoS ONE | pmid:22438967 |
| Bar-Nur O et al. | Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives. | 2012 | J Mol Cell Biol | pmid:22430918 |
| Hu XL et al. | [Effects of trichostatin A on the expressions of inflammatory cytokines and toll-like receptor 4 and the acetylation of nuclear factor-κB induced by lipopolysaccharide in macrophage]. | 2012 | Sheng Li Xue Bao | pmid:23258328 |
| Rossi LE et al. | Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. | 2012 | J. Leukoc. Biol. | pmid:22124136 |
| Landreville S et al. | Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. | 2012 | Clin. Cancer Res. | pmid:22038994 |
| Colussi C et al. | P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22859492 |
| Serrat N et al. | Deacetylation of C/EBPβ is required for IL-4-induced arginase-1 expression in murine macrophages. | 2012 | Eur. J. Immunol. | pmid:22865229 |
| Kraus J | Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22823387 |
| Qiao F et al. | Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells. | 2012 | Oncol. Rep. | pmid:22825043 |
| Shao G et al. | [Effect of monoamine oxidase inhibitor on the differentiation of malignant glioma cell]. | 2012 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:22826952 |
| Zhu L et al. | Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. | 2012 | Pediatr. Pulmonol. | pmid:21905265 |
| Pufahl L et al. | Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. | 2012 | J. Cell. Mol. Med. | pmid:21883892 |
| Li L et al. | Regulation of histone acetylation by NDRG2 in glioma cells. | 2012 | J. Neurooncol. | pmid:21912936 |
| Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
| McCullough SD et al. | Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23236151 |