trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Adenomyosis D062788 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Visceral Pain D059265 1 associated lipids
Inflammatory Breast Neoplasms D058922 2 associated lipids
Capsule Opacification D058442 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Small Cell Lung Carcinoma D055752 2 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Atherosclerosis D050197 85 associated lipids
Genomic Instability D042822 7 associated lipids
Mastocytoma D034801 3 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Stroke D020521 32 associated lipids
Myopathy, Central Core D020512 1 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Roseolovirus Infections D019349 1 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Rhabdoid Tumor D018335 1 associated lipids
Cystadenoma, Serous D018293 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Rhabdomyosarcoma, Embryonal D018233 1 associated lipids
Rhabdomyosarcoma, Alveolar D018232 2 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Lymphoma, Large-Cell, Anaplastic D017728 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Toscano MG et al. SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. 2015 Mol. Ther. pmid:25292191
Nordström L et al. DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. 2015 BMC Cancer pmid:25880212
Samiec M et al. Trichostatin A-mediated epigenetic transformation of adult bone marrow-derived mesenchymal stem cells biases the in vitro developmental capability, quality, and pluripotency extent of porcine cloned embryos. 2015 Biomed Res Int pmid:25866813
Hou H et al. Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model. 2015 Biomed Res Int pmid:25866784
Devaney JM et al. Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. 2015 Epigenetics pmid:25864488
Ganatra DA et al. Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells. 2015 Eye (Lond) pmid:25853442
Tao W et al. Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. 2015 Mol. Pharmacol. pmid:25852071
Bieluszewski T et al. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. 2015 BMC Plant Biol. pmid:25849764
Rumbaugh G et al. Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. 2015 Neuropsychopharmacology pmid:25837283
Acun T et al. PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. 2015 OMICS pmid:25831062
Huisman C et al. Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. 2015 Epigenetics pmid:25830725
Fujii K et al. Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. 2015 J. Cell. Physiol. pmid:25820447
Guo W et al. RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. 2015 Clin. Exp. Metastasis pmid:25579665
Kitchen MO et al. Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. 2015 Pituitary pmid:25557289
Dagnas M et al. Post-training, intrahippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice. 2015 Hippocampus pmid:25530477
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Mataki H et al. Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. 2015 J. Hum. Genet. pmid:25518741
Jeong SG and Cho GW Trichostatin A modulates intracellular reactive oxygen species through SOD2 and FOXO1 in human bone marrow-mesenchymal stem cells. 2015 Cell Biochem. Funct. pmid:25515622
Hartman H et al. Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice. 2015 Dig. Dis. Sci. pmid:25492506
Tiernan AR et al. Trichostatin A affects the secretion pathways of beta and intestinal endocrine cells. 2015 Exp. Cell Res. pmid:25305500
Rempel E et al. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. 2015 Arch. Toxicol. pmid:26272509
Dreser N et al. Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. 2015 Neurotoxicology pmid:26238599
Schlörmann W et al. Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells. 2015 Genes Nutr pmid:26559563
Wu Y et al. Acetylation-dependent function of human single-stranded DNA binding protein 1. 2015 Nucleic Acids Res. pmid:26170237
Singh RD et al. Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. 2015 Toxicol. Lett. pmid:26008221
Fukui T et al. Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. 2015 Toxicology pmid:25758465
Pinz S et al. Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. 2015 Nucleic Acids Res. pmid:25769527
Wang Y et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. 2015 Chem. Biol. pmid:25699604
Sobolewski C et al. Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. 2015 Biomolecules pmid:26343742
Brandão FA et al. Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. 2015 Virulence pmid:26103530
Sugimoto H et al. Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits. 2015 Zygote pmid:24666637
Alvarez AA et al. The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells. 2015 J. Mol. Neurosci. pmid:24874578
Rodrigues MF et al. Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. 2015 J. Cell. Biochem. pmid:25510910
Ma L et al. HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1. 2015 Mol. Endocrinol. pmid:26357899
Uchida H et al. Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. 2015 J. Pharmacol. Sci. pmid:26318673
Zhang Y et al. Effect of histone deacetylase on prostate carcinoma. 2015 Int J Clin Exp Pathol pmid:26823840
Rolando M et al. Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery. 2015 Cytoskeleton (Hoboken) pmid:26403219
Feng W et al. Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells. 2015 Biomed. Pharmacother. pmid:26349994
Li YL et al. Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer. 2015 Int J Clin Exp Pathol pmid:26339382
Zhang P et al. Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. 2015 PLoS ONE pmid:26287365
Ota C et al. Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. 2015 Exp. Lung Res. pmid:26151196
Singh AK et al. Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. 2015 Clin. Cancer Res. pmid:26130461
Lee YR et al. Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. 2015 Oncotarget pmid:26125438
Thangavel J et al. Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. 2015 J. Cell. Sci. pmid:26116574
Kanasaki H et al. Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. 2015 Mol. Cell. Endocrinol. pmid:26116234
Dupré-Aucouturier S et al. Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. 2015 J. Appl. Physiol. pmid:26112243
Liu J et al. Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. 2015 Biochem. Biophys. Res. Commun. pmid:26086099
Huang J et al. Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway. 2015 Int. J. Mol. Med. pmid:26080623
Huan Y et al. Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. 2015 PLoS ONE pmid:26068219
Huan Y et al. Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. 2015 Cell Reprogram pmid:26053519
Sharifulina SA et al. Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact. 2014 Brain Res. Bull. pmid:24502940
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Lv W et al. Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. 2014 PLoS ONE pmid:25412078
Lu HG et al. TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion. 2014 Mol Med Rep pmid:25175940
Zohre S et al. Trichostatin A-induced apoptosis is mediated by Kruppel-like factor 4 in ovarian and lung cancer. 2014 Asian Pac. J. Cancer Prev. pmid:25169491
Saini M et al. Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro. 2014 Theriogenology pmid:25151601
Tomioka T et al. The histone deacetylase inhibitor trichostatin A induces neurite outgrowth in PC12 cells via the epigenetically regulated expression of the nur77 gene. 2014 Neurosci. Res. pmid:25128386
Zhang Q et al. Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis. 2014 Cancer Lett. pmid:25109451
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Shin HJ et al. Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation. 2014 J. Virol. pmid:24227836
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Kumafuji M et al. Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. 2014 Genes Cells pmid:24840924
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Al-Rayyan N et al. 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. 2014 Cancer Lett. pmid:24513177
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Chen HY et al. Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. 2014 Pharmazie pmid:24601225
Kilinc V et al. Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism? 2014 Tumour Biol. pmid:24622883
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Kizuka Y et al. Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. 2014 J. Biol. Chem. pmid:24619417
Kondo Y et al. Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. 2014 PLoS ONE pmid:25084468
Alsarraf O et al. Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. 2014 Exp. Eye Res. pmid:25064603
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