Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Grignani F et al. | Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. | 1998 | Nature | pmid:9486655 |
Wong J et al. | Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. | 1998 | EMBO J. | pmid:9430643 |
Magnaghi-Jaulin L et al. | Retinoblastoma protein represses transcription by recruiting a histone deacetylase. | 1998 | Nature | pmid:9468140 |
Svensson K et al. | The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. | 1998 | Development | pmid:9389664 |
El Kharroubi A et al. | Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. | 1998 | Mol. Cell. Biol. | pmid:9566873 |
Gray SG and Ekström TJ | Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9571167 |
Belyaev ND et al. | The acetylation patterns of histones H3 and H4 along Vicia faba chromosomes are different. | 1998 | Chromosome Res. | pmid:9510512 |
Nan X et al. | Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. | 1998 | Nature | pmid:9620804 |
Kim YB et al. | phd1+, a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A. | 1998 | FEBS Lett. | pmid:9781677 |
Richon VM et al. | A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501205 |
Egawa K et al. | Identification of active substances from Streptomyces culture fluids using p53-independent expression of p21/WAF1/Cip1 gene and their mode of action. | 1998 | Biol. Pharm. Bull. | pmid:9781835 |
Madisen L et al. | The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes. | 1998 | Mol. Cell. Biol. | pmid:9774645 |
Eden S et al. | DNA methylation models histone acetylation. | 1998 | Nature | pmid:9732866 |
Phelan MW et al. | Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells. | 1998 | J. Lab. Clin. Med. | pmid:9851743 |
Ciana P et al. | Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo. | 1998 | EMBO J. | pmid:9857194 |
De Luca P et al. | Retinoblastoma protein tethered to promoter DNA represses TBP-mediated transcription. | 1998 | J. Cell. Biochem. | pmid:9671233 |
Selker EU | Trichostatin A causes selective loss of DNA methylation in Neurospora. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689097 |
Jin S and Scotto KW | Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. | 1998 | Mol. Cell. Biol. | pmid:9632821 |
Thompson EM and Renard JP | Preferential nuclear location of a transgene does not depend on its transcriptional activity during early mouse development. | 1998 | Chromosoma | pmid:9880765 |
Durum SK et al. | Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. | 1998 | J. Exp. Med. | pmid:9858510 |