trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Björkman M et al. | Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. | 2008 | Int. J. Cancer | pmid:18798265 |
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| Hayashi K et al. | Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. | 2008 | Cell Stem Cell | pmid:18940731 |
| Ridolfi E et al. | Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. | 2008 | Br. J. Cancer | pmid:18941460 |
| Zhang S et al. | Effect of trichostatin a on viability and microRNA expression in human pancreatic cancer cell line BxPC-3. | 2008 | Exp. Oncol. | pmid:19112422 |
| Hajji N et al. | Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. | 2008 | Oncogene | pmid:18071312 |
| Walton TJ et al. | DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. | 2008 | Prostate | pmid:18092350 |
| Arany I et al. | Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18094030 |
| Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
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| Fantini D et al. | APE1/Ref-1 regulates PTEN expression mediated by Egr-1. | 2008 | Free Radic. Res. | pmid:18324520 |
| Kang JH et al. | CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. | 2008 | J. Cell. Biochem. | pmid:18275041 |
| Oliva J et al. | Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. | 2008 | Exp. Mol. Pathol. | pmid:18280469 |
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| Jensen TJ et al. | Epigenetic remodeling during arsenical-induced malignant transformation. | 2008 | Carcinogenesis | pmid:18448484 |
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| Lee EJ et al. | Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. | 2008 | Int. J. Oncol. | pmid:18813790 |
| Cheli Y et al. | Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. | 2007 Sep-Oct | Biochim. Biophys. Acta | pmid:17669516 |
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| Choy SW et al. | C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17506990 |
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| Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
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| Mayo C et al. | In vitro differentiation of HT-29 M6 mucus-secreting colon cancer cells involves a trychostatin A and p27(KIP1)-inducible transcriptional program of gene expression. | 2007 | J. Cell. Physiol. | pmid:17311291 |
| Avila AM et al. | Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. | 2007 | J. Clin. Invest. | pmid:17318264 |
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| Horion J et al. | Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha. | 2007 | J. Biol. Chem. | pmid:17409387 |
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| Kim EJ et al. | Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. | 2007 | Mol. Cell | pmid:17964266 |
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| Jaffe RC et al. | Histone deacetylase inhibition and progesterone act synergistically to stimulate baboon glycodelin gene expression. | 2007 | J. Mol. Endocrinol. | pmid:17339403 |
| Alimirah F et al. | IFI16 in human prostate cancer. | 2007 | Mol. Cancer Res. | pmid:17339605 |
| Wu Y and Guo SW | Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells. | 2007 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17296257 |
| Cao D et al. | COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17395887 |