Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Anderson I | Deacetylase inhibitors aid recovery in muscular dystrophy. | 2006 | Lancet Neurol | pmid:17089447 |
Vinken M et al. | Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. | 2006 | Toxicol. Sci. | pmid:16531468 |
Gastaldi T et al. | Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation. | 2006 | Carcinogenesis | pmid:16537559 |
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Armstrong K et al. | NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. | 2006 | Prostate | pmid:16683270 |
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Kim Y et al. | Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. | 2006 | J. Steroid Biochem. Mol. Biol. | pmid:16723222 |
Santander VS et al. | Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. | 2006 | Mol. Cell. Biochem. | pmid:16733802 |
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Dannenberg LO et al. | Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. | 2006 | Alcohol. Clin. Exp. Res. | pmid:16737450 |
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Scott SA et al. | 5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. | 2006 | Leuk. Res. | pmid:16043219 |
Hofmann A et al. | Epigenetic regulation of lentiviral transgene vectors in a large animal model. | 2006 | Mol. Ther. | pmid:16140581 |
Mai A et al. | Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. | 2006 | J. Med. Chem. | pmid:17004718 |
Yao J et al. | NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. | 2006 | Pharmacol. Res. | pmid:17005413 |
Jung JW et al. | Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. | 2006 | Cancer Lett. | pmid:16337085 |
Claus R et al. | Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. | 2006 | J. Leukoc. Biol. | pmid:17000900 |
Kogai T et al. | Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. | 2006 | Endocr. Relat. Cancer | pmid:16954431 |
Tyson-Capper AJ et al. | Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. | 2006 | Mol. Hum. Reprod. | pmid:16959971 |
Chen J et al. | Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells. | 2006 | Pharmazie | pmid:16964716 |
Kim MY et al. | A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16924111 |
Mühlethaler-Mottet A et al. | Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. | 2006 | BMC Cancer | pmid:16930472 |
Weaver IC et al. | Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16484373 |
Fandy TE and Srivastava RK | Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. | 2006 | Cancer Chemother. Pharmacol. | pmid:16435155 |
Deng G et al. | Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. | 2006 | Int. J. Cancer | pmid:16425274 |
Huang L et al. | Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. | 2006 | Neurosci. Lett. | pmid:16426753 |
Kim IA et al. | Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. | 2006 | Clin. Cancer Res. | pmid:16467109 |
Osborn NK et al. | Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. | 2006 | Clin. Gastroenterol. Hepatol. | pmid:16469682 |
Cecconi D et al. | Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335935 |
Garcia BA et al. | Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335948 |
Huang W et al. | Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. | 2005 | J. Biol. Chem. | pmid:15647279 |
Choi JH et al. | Trichostatin A attenuates airway inflammation in mouse asthma model. | 2005 | Clin. Exp. Allergy | pmid:15649272 |
Chen J and Kang JH | Quercetin and trichostatin A cooperatively kill human leukemia cells. | 2005 | Pharmazie | pmid:16320950 |
Wei M et al. | BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. | 2005 | Cancer Res. | pmid:16322213 |
Marchion DC et al. | Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. | 2005 | Clin. Cancer Res. | pmid:16322310 |
Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
Place RF et al. | HDACs and the senescent phenotype of WI-38 cells. | 2005 | BMC Cell Biol. | pmid:16250917 |
Lee JH et al. | Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1. | 2005 | J. Endocrinol. | pmid:16293776 |
Hazzalin CA and Mahadevan LC | Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. | 2005 | PLoS Biol. | pmid:16262446 |
Hohl M and Thiel G | Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. | 2005 | Eur. J. Neurosci. | pmid:16262660 |
Hammond SM et al. | Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia. | 2005 | Leuk. Res. | pmid:15541480 |
Chang S and Pikaard CS | Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. | 2005 | J. Biol. Chem. | pmid:15516340 |
Ishihara K | [Role of eosinophils in allergic inflammation]. | 2005 | Yakugaku Zasshi | pmid:16141691 |
Lu Q et al. | Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. | 2005 | J. Med. Chem. | pmid:16107152 |
Yanada M et al. | Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. | 2005 | Oncol. Rep. | pmid:16142337 |
Uchida H et al. | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2005 | Endocrinology | pmid:16123169 |
Su M et al. | Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells. | 2005 | J. Biol. Chem. | pmid:16087680 |
Somech R et al. | The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. | 2005 | J. Cell. Sci. | pmid:16129885 |
Cho HH et al. | Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. | 2005 | J. Cell. Biochem. | pmid:16088945 |
Lin KT et al. | Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. | 2005 | J. Biomed. Sci. | pmid:16132114 |
Smardová J et al. | CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. | 2005 | Differentiation | pmid:16026544 |
Fandy TE et al. | Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. | 2005 | Neoplasia | pmid:16026644 |
Korutla L et al. | The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. | 2005 | J. Neurochem. | pmid:16033423 |
Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
Kemp MG et al. | The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. | 2005 | Nucleic Acids Res. | pmid:15653633 |
Peltonen K et al. | Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis. | 2005 | Pigment Cell Res. | pmid:15892716 |
Schwahn DJ et al. | Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. | 2005 | Pigment Cell Res. | pmid:15892717 |
Ranganathan P and Rangnekar VM | Exploiting the TSA connections to overcome apoptosis-resistance. | 2005 | Cancer Biol. Ther. | pmid:15908800 |
Rincón-Arano H et al. | YY1 and GATA-1 interaction modulate the chicken 3'-side alpha-globin enhancer activity. | 2005 | J. Mol. Biol. | pmid:15913647 |
Galfi P et al. | Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862948 |
Choi KH et al. | Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine. | 2005 | Glycoconj. J. | pmid:15864436 |
Touma SE et al. | Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. | 2005 | Clin. Cancer Res. | pmid:15867260 |
Sng JC et al. | Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation. | 2005 | Neurosci. Lett. | pmid:16002216 |
Sonnemann J et al. | Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. | 2005 | Invest New Drugs | pmid:15744585 |
Shetty S et al. | Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. | 2005 | Mol. Cell. Biol. | pmid:15964798 |
Place RF et al. | HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. | 2005 | Biochem. Pharmacol. | pmid:15950952 |
Wooten LG and Ogretmen B | Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. | 2005 | J. Biol. Chem. | pmid:15951564 |
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Whang YM et al. | Hyperacetylation enhances the growth-inhibitory effect of all-trans retinoic acid by the restoration of retinoic acid receptor beta expression in head and neck squamous carcinoma (HNSCC) cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15959780 |
Gunin AG et al. | Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. | 2005 | J. Endocrinol. | pmid:15930180 |
Komata T et al. | Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. | 2005 | Int. J. Oncol. | pmid:15809727 |
Wittich S et al. | Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. | 2005 | Anticancer Drugs | pmid:15930892 |
Kaneda R et al. | Genome-wide screening for target regions of histone deacetylases in cardiomyocytes. | 2005 | Circ. Res. | pmid:16002748 |
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Xu S et al. | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. | 2005 | J. Hum. Genet. | pmid:15824892 |
Strait KA et al. | Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. | 2005 | Mol. Cancer Ther. | pmid:15827334 |
Fishel ML et al. | Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15304523 |
Magner WJ and Tomasi TB | Apoptotic and necrotic cells induced by different agents vary in their expression of MHC and costimulatory genes. | 2005 | Mol. Immunol. | pmid:15829293 |
Hu J and Colburn NH | Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. | 2005 | Mol. Cancer Res. | pmid:15755876 |
Wagner S and Roemer K | Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. | 2005 | Biochem. Pharmacol. | pmid:15763542 |
Kawamura T et al. | Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. | 2005 | J. Biol. Chem. | pmid:15764815 |
Xiong Y et al. | Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. | 2005 | Cancer Res. | pmid:15805266 |
Kumakura S et al. | Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. | 2005 | Cancer Res. | pmid:15805278 |
Zhao W et al. | The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. | 2005 | J. Biochem. | pmid:15809347 |
Senawong T et al. | BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. | 2005 | Arch. Biochem. Biophys. | pmid:15639232 |
Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |
Fujisawa K et al. | Epigenetic status and aberrant expression of the maspin gene in human hepato-biliary tract carcinomas. | 2005 | Lab. Invest. | pmid:15608662 |
Bottardi S et al. | Onset and inheritance of abnormal epigenetic regulation in hematopoietic cells. | 2005 | Hum. Mol. Genet. | pmid:15615768 |
Ezzat S et al. | The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. | 2005 | Mol. Endocrinol. | pmid:15618287 |