trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Henderson C et al. | Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). | 2003 | J. Biol. Chem. | pmid:12556448 |
| Palazzo A et al. | Cell biology: Tubulin acetylation and cell motility. | 2003 | Nature | pmid:12529632 |
| Fernandes I et al. | Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. | 2003 | Mol. Cell | pmid:12535528 |
| Cheutin T et al. | Maintenance of stable heterochromatin domains by dynamic HP1 binding. | 2003 | Science | pmid:12560555 |
| Boutillier AL et al. | Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. | 2003 | J. Neurochem. | pmid:12562525 |
| Tomita K et al. | The effect of oxidative stress on histone acetylation and IL-8 release. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565901 |
| Rahman MM et al. | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. | 2003 | Blood | pmid:12511413 |
| Musikacharoen T et al. | Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. | 2003 | J. Biol. Chem. | pmid:12511574 |
| Gusterson RJ et al. | The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. | 2003 | J. Biol. Chem. | pmid:12477714 |
| Kondo Y et al. | Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. | 2003 | Mol. Cell. Biol. | pmid:12482974 |
| James SY et al. | Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. | 2003 | Cancer Res. | pmid:12839938 |
| Ding Z et al. | Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. | 2003 | Mol. Cell. Biol. | pmid:12482978 |
| Haggarty SJ et al. | Small molecule modulation of the human chromatid decatenation checkpoint. | 2003 | Chem. Biol. | pmid:14700634 |
| Kim DK et al. | Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14667227 |
| Obata T et al. | Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. | 2003 | Clin. Cancer Res. | pmid:14695142 |
| Terui T et al. | Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. | 2003 | Cancer Res. | pmid:14695212 |
| Hong CY et al. | Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B. | 2003 | Mol. Cell. Biol. | pmid:12917325 |
| Le Masson I et al. | Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. | 2003 | Mol. Cell. Biol. | pmid:12917332 |
| Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
| Condon JC et al. | A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12886011 |
| Ryu JR and Arnosti DN | Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. | 2003 | Nucleic Acids Res. | pmid:12888527 |
| Pivot-Pajot C et al. | Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. | 2003 | Mol. Cell. Biol. | pmid:12861021 |
| Grassi G et al. | Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. | 2003 | Carcinogenesis | pmid:12869421 |
| Ammanamanchi S et al. | Acetylated sp3 is a transcriptional activator. | 2003 | J. Biol. Chem. | pmid:12837748 |
| Kawai H et al. | Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. | 2003 | Int. J. Cancer | pmid:14506733 |
| Kishikawa S et al. | Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. | 2003 | Nucleic Acids Res. Suppl. | pmid:14510503 |
| Wegener D et al. | Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. | 2003 | Anal. Biochem. | pmid:14511685 |
| Lopatina NG et al. | Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12810068 |
| Liu LT et al. | Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. | 2003 | Cancer Res. | pmid:12810630 |
| Shin HJ et al. | Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. | 2003 | Oncogene | pmid:12813458 |
| Kim TY et al. | Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. | 2003 | Oncogene | pmid:12813468 |
| Kim JM et al. | Changes in histone acetylation during mouse oocyte meiosis. | 2003 | J. Cell Biol. | pmid:12835313 |
| Camarero N et al. | Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. | 2003 | Nucleic Acids Res. | pmid:12626711 |
| Park KK et al. | Modulation of Sp1-dependent transcription by a cis-acting E2F element in dhfr promoter. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788094 |
| Marks J et al. | Two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter. | 2003 | J. Biol. Chem. | pmid:12791684 |
| Valls E et al. | The SV40 T antigen modulates CBP histone acetyltransferase activity. | 2003 | Nucleic Acids Res. | pmid:12799439 |
| Ferguson M et al. | Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. | 2003 | Nucleic Acids Res. | pmid:12799440 |
| Hirose T et al. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | 2003 | Oncogene | pmid:14586402 |
| Brugarolas JB et al. | TSC2 regulates VEGF through mTOR-dependent and -independent pathways. | 2003 | Cancer Cell | pmid:12957289 |
| Cimini D et al. | Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. | 2003 | Mol. Biol. Cell | pmid:12972566 |
| Schuettengruber B et al. | Autoregulation of mouse histone deacetylase 1 expression. | 2003 | Mol. Cell. Biol. | pmid:12972616 |
| Yang Y et al. | The histone code regulating expression of the imprinted mouse Igf2r gene. | 2003 | Endocrinology | pmid:12975326 |
| Hu E et al. | Identification of novel isoform-selective inhibitors within class I histone deacetylases. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12975486 |
| Craig JM et al. | Centromeric chromatin pliability and memory at a human neocentromere. | 2003 | EMBO J. | pmid:12743043 |
| Enright BP et al. | Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine. | 2003 | Biol. Reprod. | pmid:12748129 |
| Van Ommeslaeghe K et al. | Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12749885 |
| Zhao S et al. | Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. | 2003 | Cancer Res. | pmid:12750289 |
| Bouchain G et al. | Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:12593661 |
| Castro-Galache MD et al. | Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. | 2003 | Int. J. Cancer | pmid:12594812 |
| Teyssier C et al. | Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. | 2003 | Mol. Endocrinol. | pmid:12554755 |