| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kurtev V et al. | Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. | 2004 | J. Biol. Chem. | pmid:15140878 |
| Kim YH et al. | Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. | 2004 | Carcinogenesis | pmid:15142888 |
| Kato N et al. | Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. | 2004 | Cell Death Differ. | pmid:15153943 |
| Zoumpoulidou G et al. | Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). | 2004 | Mol. Endocrinol. | pmid:15155784 |
| Wang LG et al. | Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. | 2004 | Oncogene | pmid:15156193 |
| Zhang Y et al. | Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. | 2004 | Radiat. Res. | pmid:15161353 |
| Glenn MP et al. | Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. | 2004 | J. Med. Chem. | pmid:15163181 |
| Ronai D et al. | The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature. | 2004 | Genetics | pmid:15166165 |
| Zhang X et al. | Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. | 2004 | Mol. Cell. Biol. | pmid:15169878 |
| Lee YJ et al. | Mechanism of transcriptional repression by TEL/RUNX1 fusion protein. | 2004 | Mol. Cells | pmid:15179033 |
| Flørenes VA et al. | Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. | 2004 | Melanoma Res. | pmid:15179185 |
| Ahn MR et al. | Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. | 2004 | Arch. Pharm. Res. | pmid:15180307 |
| Vanhaecke T et al. | Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. | 2004 | Curr. Med. Chem. | pmid:15180568 |
| Ishiguro K and Sartorelli AC | Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. | 2004 | Eur. J. Biochem. | pmid:15182353 |
| Brieger A et al. | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | 2004 | Biochem. Pharmacol. | pmid:15183120 |
| Sakamoto S et al. | Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. | 2004 | J. Biol. Chem. | pmid:15194680 |
| Ng Y et al. | Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. | 2004 | J. Biol. Chem. | pmid:15194684 |
| Lu H et al. | Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. | 2004 | J. Virol. | pmid:15194748 |
| Moldenhauer A et al. | Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins. | 2004 | J. Leukoc. Biol. | pmid:15197237 |
| Min KN et al. | Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15202563 |
| Korzus E et al. | CBP histone acetyltransferase activity is a critical component of memory consolidation. | 2004 | Neuron | pmid:15207240 |
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| Jia S et al. | RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. | 2004 | Science | pmid:15218150 |
| Sumer H et al. | Effects of scaffold/matrix alteration on centromeric function and gene expression. | 2004 | J. Biol. Chem. | pmid:15220334 |
| Fang JY et al. | Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116. | 2004 | Cell Res. | pmid:15225415 |
| Banwell CM et al. | Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15225779 |
| Mao DY et al. | Promoter-binding and repression of PDGFRB by c-Myc are separable activities. | 2004 | Nucleic Acids Res. | pmid:15226411 |
| Naruse Y et al. | Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. | 2004 | Mol. Cell. Biol. | pmid:15226430 |
| Chen WK et al. | [Effect of trichostatin A on histone acetylation level and apoptosis in HL-60 cells]. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15228659 |
| Kim JH et al. | Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. | 2004 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:15234053 |
| De La Fuente R et al. | ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. | 2004 | Dev. Biol. | pmid:15242786 |
| Kang J et al. | Synergistic killing of human leukemia cells by antioxidants and trichostatin A. | 2004 | Cancer Chemother. Pharmacol. | pmid:15248029 |
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| Aggarwal BD and Calvi BR | Chromatin regulates origin activity in Drosophila follicle cells. | 2004 | Nature | pmid:15254542 |
| Marengo E et al. | Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. | 2004 | Anal Bioanal Chem | pmid:15257427 |
| Schauber J et al. | Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. | 2004 | Mol. Immunol. | pmid:15261456 |
| Sanderson L et al. | Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. | 2004 | Drug Metab. Dispos. | pmid:15269190 |
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| Joung KE et al. | Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15283467 |
| Iijima K et al. | Granulocytic differentiation of leukemic cells with t(9;11)(p22;q23) induced by all-trans-retinoic acid. | 2004 | Leuk. Lymphoma | pmid:15291362 |
| Fenic I et al. | In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. | 2004 Sep-Oct | J. Androl. | pmid:15292114 |
| Tóth KF et al. | Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin. | 2004 | J. Cell. Sci. | pmid:15292402 |
| Fishel ML et al. | Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15304523 |
| Yanaihara N et al. | Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. | 2004 | Int. J. Cancer | pmid:15305387 |
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