trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Meng CF et al. [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. 2009 Zhonghua Wei Chang Wai Ke Za Zhi pmid:19742343
Zheng L et al. [Detecting acetylated proteins by affinity chromatography column]. 2012 Zhonghua Xue Ye Xue Za Zhi pmid:22781610
Sun DF et al. [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. 2007 Zhonghua Yi Xue Yi Chuan Xue Za Zhi pmid:17680526
Chen YX et al. [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. 2004 Zhonghua Yi Xue Za Zhi pmid:15059516
Wang CT and Meng M [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. 2007 Zhonghua Yi Xue Za Zhi pmid:17650409
Jiang SJ et al. [Effects of trichostatin A and paclitaxel on apoptosis and microtubule stabilization in endometrial carcinoma cells: an in vitro research]. 2008 Zhonghua Yi Xue Za Zhi pmid:19087722
Ma XL et al. [Construction of anti-sense cDNA library of human breast cancer cells during apoptosis induced by trichostatin A and preliminary screening of essential genes]. 2009 Zhonghua Yi Xue Za Zhi pmid:19567099
Qi J et al. [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. 2007 Zhonghua Yi Xue Za Zhi pmid:17923031
Ji S et al. [Association of irradiation-induced hippocampal neurogenesis impairment with histone H3 acetylation]. 2015 Zhonghua Yi Xue Za Zhi pmid:26168675
Fan J et al. [Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]. 2006 Zhonghua Zhong Liu Za Zhi pmid:17533736
Zhang S et al. [Effect of trichostatin A and paclitaxel on the growth and apoptosis of lung adenocarcinoma cell lines]. 2012 Zhonghua Zhong Liu Za Zhi pmid:22967465
Qi J et al. [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. 2007 Zhonghua Zhong Liu Za Zhi pmid:18396643
Wu P et al. [Role of human telomerase reverse transcriptase in apoptosis of human umbilical vein endothelial cells induced by trichostatin A]. 2007 Zhonghua Zhong Liu Za Zhi pmid:17892126
Ikeda S et al. Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts. 2009 Zygote pmid:19356267
Bo F et al. Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. 2011 Zygote pmid:20569515
Mousai M et al. Effect of epigenetic modification with trichostatin A and S-adenosylhomocysteine on developmental competence and POU5F1-EGFP expression of interspecies cloned embryos in dog. 2015 Zygote pmid:25314965
Burlibaşa L and Gavrilă L Molecular and ultrastructural studies of the sperm chromatin from Triturus cristatus. 2005 Zygote pmid:16261764
Segev H et al. Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development. 2001 Zygote pmid:11358320
Petr J et al. Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocytes. 2009 Zygote pmid:19460191
Sugimoto H et al. Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits. 2015 Zygote pmid:24666637
Ning SF et al. Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. 2013 Zygote pmid:22355002
Oliveira CS et al. Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos. 2013 Zygote pmid:21867598
Jee BC et al. Effect of trichostatin A on fertilization and embryo development during extended culture of mouse oocyte. 2012 Zygote pmid:21269543
Jeseta M et al. In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A. 2008 Zygote pmid:18405435
Selokar NL et al. Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. 2016 Zygote pmid:26503476
Tsuji Y et al. The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2'-deoxycytidine. 2009 Zygote pmid:19175955