| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xie M et al. | Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:25352747 |
| Xiong J et al. | USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. | 2014 | Mol Med Rep | pmid:25323692 |
| Li G et al. | Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue. | 2014 | J. Nutr. | pmid:25320182 |
| Ishihara K | Eosinophil cell lines. | 2014 | Methods Mol. Biol. | pmid:24986606 |
| Liu H et al. | The Smn-independent beneficial effects of trichostatin A on an intermediate mouse model of spinal muscular atrophy. | 2014 | PLoS ONE | pmid:24984019 |
| Maldonado L et al. | An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. | 2014 | Oncotarget | pmid:24980822 |
| Wilson-Edell KA et al. | RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. | 2014 | Oncotarget | pmid:24970821 |
| Yang XL et al. | Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24969901 |
| Hu Z and Wang J | Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells. | 2014 | Cell Reprogram | pmid:24945595 |
| Ma H et al. | HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. | 2014 | Int J Mol Sci | pmid:24941254 |
| Lee J et al. | Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS). | 2014 | Curr. Med. Chem. | pmid:25005187 |
| He G et al. | Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. | 2014 | Tumour Biol. | pmid:24122231 |
| Mathiyalagan P et al. | The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. | 2014 | Nucleic Acids Res. | pmid:24137001 |
| Tu CY et al. | Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. | 2014 | Biomed Res Int | pmid:24707474 |
| Zhang YW et al. | Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. | 2014 | Epigenetics | pmid:24699858 |
| Boyer JG et al. | Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. | 2014 | Hum. Mol. Genet. | pmid:24691550 |
| Deneberg S et al. | microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. | 2014 | Epigenetics | pmid:24686393 |
| Zuo X et al. | Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. | 2014 | Oncol. Rep. | pmid:24676336 |
| Zou JY and Crews FT | Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. | 2014 | PLoS ONE | pmid:24551070 |
| Guilluy C et al. | Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. | 2014 | Nat. Cell Biol. | pmid:24609268 |
| Fetahu IS et al. | Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. | 2014 | Int. J. Cancer | pmid:24691920 |
| Serrat N et al. | The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ. | 2014 | J. Immunol. | pmid:24307736 |
| Hou SY et al. | Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. | 2014 | Arch. Med. Res. | pmid:24316396 |
| Johnson JL et al. | The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. | 2014 | J. Invest. Dermatol. | pmid:24594668 |
| Chu Y et al. | Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. | 2014 | Cell. Mol. Life Sci. | pmid:24531693 |
| Herr MJ et al. | Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24747564 |
| Devaney JM et al. | Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. | 2015 | Epigenetics | pmid:25864488 |
| Ganatra DA et al. | Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells. | 2015 | Eye (Lond) | pmid:25853442 |
| Tao W et al. | Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. | 2015 | Mol. Pharmacol. | pmid:25852071 |
| Bieluszewski T et al. | AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. | 2015 | BMC Plant Biol. | pmid:25849764 |
| Rumbaugh G et al. | Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. | 2015 | Neuropsychopharmacology | pmid:25837283 |
| Acun T et al. | PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. | 2015 | OMICS | pmid:25831062 |
| Dagnas M et al. | Post-training, intrahippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice. | 2015 | Hippocampus | pmid:25530477 |
| Qiao Y et al. | Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. | 2015 | J. Biol. Chem. | pmid:25519907 |
| Mataki H et al. | Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. | 2015 | J. Hum. Genet. | pmid:25518741 |
| Rempel E et al. | A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. | 2015 | Arch. Toxicol. | pmid:26272509 |
| Dreser N et al. | Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. | 2015 | Neurotoxicology | pmid:26238599 |
| Wu Y et al. | Acetylation-dependent function of human single-stranded DNA binding protein 1. | 2015 | Nucleic Acids Res. | pmid:26170237 |
| Singh RD et al. | Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. | 2015 | Toxicol. Lett. | pmid:26008221 |
| Sobolewski C et al. | Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. | 2015 | Biomolecules | pmid:26343742 |
| Brandão FA et al. | Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. | 2015 | Virulence | pmid:26103530 |
| Alvarez AA et al. | The effects of histone deacetylase inhibitors on glioblastoma-derived stem cells. | 2015 | J. Mol. Neurosci. | pmid:24874578 |
| Ma L et al. | HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1. | 2015 | Mol. Endocrinol. | pmid:26357899 |
| Zhang Y et al. | Effect of histone deacetylase on prostate carcinoma. | 2015 | Int J Clin Exp Pathol | pmid:26823840 |
| Feng W et al. | Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells. | 2015 | Biomed. Pharmacother. | pmid:26349994 |
| Li YL et al. | Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer. | 2015 | Int J Clin Exp Pathol | pmid:26339382 |
| Thangavel J et al. | Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. | 2015 | J. Cell. Sci. | pmid:26116574 |
| Kanasaki H et al. | Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. | 2015 | Mol. Cell. Endocrinol. | pmid:26116234 |
| Dupré-Aucouturier S et al. | Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. | 2015 | J. Appl. Physiol. | pmid:26112243 |
| Liu J et al. | Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086099 |