trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Lam YM et al. Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo. 2017 Int. J. Hematol. pmid:27531147
Scholpa NE et al. Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer. 2016 Chem. Biol. Interact. pmid:27543423
Vargas-López V et al. Histone deacetylase inhibition abolishes stress-induced spatial memory impairment. 2016 Neurobiol Learn Mem pmid:27544851
Zhang XF et al. Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. 2016 Int J Mol Sci pmid:27548148
Sugiyama KI et al. Epigenetic mutagen as histone modulator can be detected by yeast flocculation. 2016 Mutagenesis pmid:27549112
Díaz-Núñez M et al. Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. 2016 BMC Cancer pmid:27549189
Duffy S et al. Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:27551064
Kotantaki P and Mosialos G The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. 2016 Cell Biochem. Funct. pmid:27570065
Ho TT et al. Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. 2016 Int J Biochem Mol Biol pmid:27570640
Park IH et al. Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. 2016 PLoS ONE pmid:27571418
Tiper IV and Webb TJ Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. 2016 Cancer Immunol. Immunother. pmid:27614429
Desjardins D et al. Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. 2016 PLoS ONE pmid:27617745
Zhang Q et al. Trichostatin A protects against intestinal injury in rats with acute liver failure. 2016 J. Surg. Res. pmid:27620992
Chen W et al. MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. 2016 Biochim. Biophys. Acta pmid:27638301
Xu Q et al. Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:27638876
Tao W et al. Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. 2016 Neuroscience pmid:27646288
Sobue S et al. Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. 2016 Biochem. Biophys. Res. Commun. pmid:27687545
Rong X et al. Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. 2016 Sci Rep pmid:27703255
Ladrech S et al. High mobility group box 1 (HMGB1): dual functions in the cochlear auditory neurons in response to stress? 2017 Histochem. Cell Biol. pmid:27704212
Hrgovic I et al. The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. 2016 BMC Cancer pmid:27716272
Morinobu A et al. Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. 2016 PLoS ONE pmid:27736946
Wisnieski F et al. BMP8B Is a Tumor Suppressor Gene Regulated by Histone Acetylation in Gastric Cancer. 2017 J. Cell. Biochem. pmid:27748538
Nadanaka S et al. Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. 2016 Biochem. Biophys. Res. Commun. pmid:27751852
Unruhe-Knauf B and Knauer SK Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization. 2017 Methods Mol. Biol. pmid:27761812
Buchou T et al. Purification and Analysis of Male Germ Cells from Adult Mouse Testis. 2017 Methods Mol. Biol. pmid:27761820
Pinz S and Rascle A Assessing HDAC Function in the Regulation of Signal Transducer and Activator of Transcription 5 (STAT5) Activity Using Chromatin Immunoprecipitation (ChIP). 2017 Methods Mol. Biol. pmid:27761827
Staberg M et al. Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine. 2017 Cell Oncol (Dordr) pmid:27766591
Bauer I et al. A Class 1 Histone Deacetylase with Potential as an Antifungal Target. 2016 MBio pmid:27803184
Zapletal O et al. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. 2017 Arch. Toxicol. pmid:27830268
Tombolan L et al. Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. 2016 BMC Cancer pmid:27842508
Choi SA et al. A novel histone deacetylase inhibitor, CKD5, has potent anti-cancer effects in glioblastoma. 2017 Oncotarget pmid:27852054
Kim HR et al. Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. 2016 PLoS ONE pmid:27855185
Huynh NC et al. Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells. 2017 Bone pmid:27871909
Deng Z et al. Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. 2016 Int. J. Biol. Sci. pmid:27877082
Jia L et al. Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. 2017 Oncol. Rep. pmid:27878285
Bricambert J et al. Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. 2016 Mol Metab pmid:27900262
Cipriano M et al. The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells. 2017 Arch. Toxicol. pmid:27909741
Takamatsu G et al. Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. 2017 Biochem. Biophys. Res. Commun. pmid:27939885
Mengel A et al. Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases. 2017 Plant Physiol. pmid:27980017
Aquea F et al. Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana. 2017 Biochem. Biophys. Res. Commun. pmid:27993678
Choiniere J et al. Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. 2017 Mol. Pharmacol. pmid:28003426
Duan H et al. The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. 2017 Placenta pmid:28012453
Mazzio EA and Soliman KF HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. 2017 Cancer Genomics Proteomics pmid:28031235
Alqinyah M et al. Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. 2017 Mol. Pharmacol. pmid:28031332
Campo VA Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression. 2017 Int J Parasitol Drugs Drug Resist pmid:28038431
Pachano T et al. Epigenetics regulates transcription and pathogenesis in the parasite Trichomonas vaginalis. 2017 Cell. Microbiol. pmid:28054438
Hichino A et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. 2017 J. Biol. Chem. pmid:28057758
Chen L et al. PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. 2017 Oncotarget pmid:28060760
Cao Z et al. TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos. 2017 PLoS ONE pmid:28114389
Wang XJ et al. Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. 2017 Cell Rep pmid:28122243