trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Scott GK et al. Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. 2002 Mol. Cancer Ther. pmid:12477051
Gusterson RJ et al. The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. 2003 J. Biol. Chem. pmid:12477714
Strait KA et al. Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. 2002 Mol. Cancer Ther. pmid:12479699
Blagosklonny MV et al. Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. 2002 Mol. Cancer Ther. pmid:12481415
Kondo Y et al. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. 2003 Mol. Cell. Biol. pmid:12482974
Ding Z et al. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. 2003 Mol. Cell. Biol. pmid:12482978
Im H et al. Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. 2002 Biochemistry pmid:12484752
Boutillier AL et al. Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. 2002 Ann. N. Y. Acad. Sci. pmid:12485907
Dogra SC et al. Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. 2003 Mol. Pharmacol. pmid:12488538
Zarnegar R et al. Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. 2002 Surgery pmid:12490845
Lietz M et al. RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. 2003 Eur. J. Biochem. pmid:12492469
Yamashita Y et al. Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. 2003 Int. J. Cancer pmid:12494463
Thomas RM et al. Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen. 2003 J. Immunol. pmid:12496403
Yamashita K et al. Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. 2002 Cancer Cell pmid:12498717
Fahrner JA et al. Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. 2002 Cancer Res. pmid:12499261
Wang ZM et al. Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. 2002 Ai Zheng pmid:12508652
Rahman MM et al. Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. 2003 Blood pmid:12511413
Musikacharoen T et al. Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. 2003 J. Biol. Chem. pmid:12511574
Palazzo A et al. Cell biology: Tubulin acetylation and cell motility. 2003 Nature pmid:12529632
Fernandes I et al. Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. 2003 Mol. Cell pmid:12535528
Sonoyama K et al. Upregulation of activin A gene by butyrate in human colon cancer cell lines. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12540370
Kagoshima M et al. Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. 2003 Biochem. Soc. Trans. pmid:12546654
Teyssier C et al. Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. 2003 Mol. Endocrinol. pmid:12554755
Henderson C et al. Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). 2003 J. Biol. Chem. pmid:12556448
Cheutin T et al. Maintenance of stable heterochromatin domains by dynamic HP1 binding. 2003 Science pmid:12560555
Boutillier AL et al. Selective E2F-dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis. 2003 J. Neurochem. pmid:12562525
Tomita K et al. The effect of oxidative stress on histone acetylation and IL-8 release. 2003 Biochem. Biophys. Res. Commun. pmid:12565901
Kao HH et al. Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. 2003 Jan-Feb J. Biomed. Sci. pmid:12566991
Bhat RA et al. Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. 2003 Plant J. pmid:12581304
Jang IC et al. Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. 2003 Plant J. pmid:12581311
Kim Y et al. Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. 2003 Oncogene pmid:12584561
López-Solache I et al. Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. 2002 Endocrine pmid:12588052
Mishra N et al. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. 2003 J. Clin. Invest. pmid:12588892
Glaser KB et al. Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. 2003 Mol. Cancer Ther. pmid:12589032
Bouchain G et al. Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. 2003 J. Med. Chem. pmid:12593661
Castro-Galache MD et al. Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. 2003 Int. J. Cancer pmid:12594812
Ailenberg M and Silverman M Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. 2003 Biochem. Biophys. Res. Commun. pmid:12604329
Sakai N et al. Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. 2003 J. Biol. Chem. pmid:12609987
Kim SY et al. Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. 2003 J. Virol. pmid:12610114
Wang S and Zhu J Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. 2003 J. Biol. Chem. pmid:12611896
Shaker S et al. Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. 2003 Leuk. Res. pmid:12620295
Sawa H et al. Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. 2002 Brain Tumor Pathol pmid:12622137
Camarero N et al. Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site. 2003 Nucleic Acids Res. pmid:12626711
Huang Y et al. Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. 2003 Int. J. Cancer pmid:12640681
Shi W et al. Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos. 2003 Biol. Reprod. pmid:12646489
Murumägi A et al. Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. 2003 J. Biol. Chem. pmid:12651856
Chandler SP et al. Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. 2003 BMC Mol. Biol. pmid:12659659
Kao GD et al. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. 2003 J. Cell Biol. pmid:12668657
Vos MD et al. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. 2003 J. Biol. Chem. pmid:12676952
Detich N et al. The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. 2003 J. Biol. Chem. pmid:12676953