|MeSH term||MeSH ID||Detail|
|Adenocarcinoma||D000230||166 associated lipids|
|Alzheimer Disease||D000544||76 associated lipids|
|Thyroid Neoplasms||D013964||33 associated lipids|
|Carcinoma, Lewis Lung||D018827||22 associated lipids|
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
|Disease||Cross reference||Weighted score||Related literature|
We collected disease MeSH terms mapped to the references associated with Tautomycetin
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
|Pathway name||Related literatures|
Associated locations are in red color. Not associated locations are in black.
|Function||Cross reference||Weighted score||Related literatures|
|Lipid concept||Cross reference||Weighted score||Related literatures|
There are no associated biomedical information in the current reference collection.
|Ubukata M||The logic of biologically active small molecules: amazing ability of microorganisms.||2018||Biosci. Biotechnol. Biochem.||pmid:29561233|
|Choy MS et al.||PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.||2017||J. Am. Chem. Soc.||pmid:29156132|
|Choi SS et al.||Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412.||2017||J. Ind. Microbiol. Biotechnol.||pmid:27734184|
|Li M et al.||TmcN is involved in ATP regulation of tautomycetin biosynthesis in Streptomyces griseochromogenes.||2016||Biochem. Biophys. Res. Commun.||pmid:27444385|
|Tripathi A et al.||Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.||2016||J. Ind. Microbiol. Biotechnol.||pmid:27277081|
|Stockwell J et al.||Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury.||2016||Neuropharmacology||pmid:26626486|
|Gu M et al.||Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation.||2014||J. Immunol.||pmid:24534530|
|An BC et al.||Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli.||2014||Biochemistry||pmid:25402663|
|Niu M et al.||Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells.||2013||J. Pharmacol. Sci.||pmid:23269238|
|Nah JH et al.||Identification and characterization of wblA-dependent tmcT regulation during tautomycetin biosynthesis in Streptomyces sp. CK4412.||2012 Jan-Feb||Biotechnol. Adv.||pmid:21624452|