MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Tautomycetin
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid: | ||||
Lu Y et al. | Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18094148 |
Scaglione JB et al. | Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20623733 |
Walsh JE and Young MR | Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells. | 2010 | Anticancer Res. | pmid:21187463 |
Li M et al. | TmcN is involved in ATP regulation of tautomycetin biosynthesis in Streptomyces griseochromogenes. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27444385 |
Mitsuhashi S et al. | Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554729 |
An BC et al. | Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli. | 2014 | Biochemistry | pmid:25402663 |
Breton M et al. | Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly. | 2009 | Biophys. Chem. | pmid:19744766 |
Sakuda S et al. | Isolation of tautomycetin as a regulator of secondary metabolite production for Penicillium urticae. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7765963 |
Li Y et al. | Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22451389 |