| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Total
4
Tautomycetin
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
Cross Reference
Introduction
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tautomycetin?
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tautomycetin
PubChem Associated disorders and diseases
What pathways are associated with Tautomycetin
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- Mol. Cancer Ther. (2)
- Microbiology (Reading, Engl.) (2)
- Proc. Natl. Acad. Sci. U.S.A. (1)
- Others (1)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tautomycetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Mol. Cancer Ther. (2)
- Microbiology (Reading, Engl.) (2)
- Proc. Natl. Acad. Sci. U.S.A. (1)
- Others (1)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Tautomycetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tautomycetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Tautomycetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tautomycetin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Tautomycetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mitsuhashi S et al. | Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. | 2003 | J. Biol. Chem. | pmid:12374792 |
| Kakiya N et al. | Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. | 2012 | J. Biol. Chem. | pmid:22767595 |
| Gu M et al. | Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation. | 2014 | J. Immunol. | pmid:24534530 |
| Choi SS et al. | Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:27734184 |
| Park SH et al. | Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. | 2009 | J. Ind. Microbiol. Biotechnol. | pmid:19408025 |
| Kim D et al. | Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22733296 |
| Tripathi A et al. | Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:27277081 |
| Wang F et al. | Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin. | 2012 | J. Microbiol. | pmid:23124744 |
| Li W et al. | Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. | 2009 | J. Nat. Prod. | pmid:19191560 |
| Niu M et al. | Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. | 2013 | J. Pharmacol. Sci. | pmid:23269238 |