MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tautomycetin
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kim D et al. | Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22733296 |
Gu M et al. | Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation. | 2014 | J. Immunol. | pmid:24534530 |
Mitsuhashi S et al. | Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. | 2003 | J. Biol. Chem. | pmid:12374792 |
Kakiya N et al. | Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. | 2012 | J. Biol. Chem. | pmid:22767595 |
Cheng XC et al. | The structure of tautomycetin, a dialkylmaleic anhydride antibiotic. | 1990 | J. Antibiot. | pmid:2387780 |
Cheng XC et al. | A new antibiotic, tautomycetin. | 1989 | J. Antibiot. | pmid:2921220 |
Choy MS et al. | PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. | 2017 | J. Am. Chem. Soc. | pmid:29156132 |
Luo Y et al. | Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. | 2010 | J. Am. Chem. Soc. | pmid:20426415 |
Mitsuhashi S et al. | Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation. | 2008 | Int. J. Oncol. | pmid:18949366 |
Myles DC | Novel biologically active natural and unnatural products. | 2003 | Curr. Opin. Biotechnol. | pmid:14662393 |