MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tautomycetin
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lee JH et al. | Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. | 2006 | Mol. Cancer Ther. | pmid:17172426 |
Hur YA et al. | Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. | 2008 | Microbiology (Reading, Engl.) | pmid:18832298 |
Choi SS et al. | Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. | 2007 | Microbiology (Reading, Engl.) | pmid:17379718 |
Swingle M et al. | Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. | 2007 | Methods Mol. Biol. | pmid:17200551 |
Niu M et al. | Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. | 2013 | J. Pharmacol. Sci. | pmid:23269238 |
Li W et al. | Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. | 2009 | J. Nat. Prod. | pmid:19191560 |
Wang F et al. | Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin. | 2012 | J. Microbiol. | pmid:23124744 |
Park SH et al. | Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. | 2009 | J. Ind. Microbiol. Biotechnol. | pmid:19408025 |
Kim D et al. | Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22733296 |
Tripathi A et al. | Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:27277081 |