MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tautomycetin
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Adler JT et al. | Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. | 2009 | Mol. Cancer Ther. | pmid:19372564 |
Ju J et al. | Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. | 2009 | Org. Lett. | pmid:19281218 |
Breton M et al. | Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly. | 2009 | Biophys. Chem. | pmid:19744766 |
Park SH et al. | Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. | 2009 | J. Ind. Microbiol. Biotechnol. | pmid:19408025 |
Walsh JE and Young MR | Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells. | 2010 | Anticancer Res. | pmid:21187463 |
Scaglione JB et al. | Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20623733 |
Luo Y et al. | Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. | 2010 | J. Am. Chem. Soc. | pmid:20426415 |
Wee YM et al. | The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model. | 2010 Jul-Aug | Mol. Med. | pmid:20440443 |
Liu S et al. | SHP2 is a target of the immunosuppressant tautomycetin. | 2011 | Chem. Biol. | pmid:21276943 |
Yang D et al. | Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. | 2012 | Org. Lett. | pmid:22339318 |