MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Tautomycetin
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yang D et al. | Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. | 2012 | Org. Lett. | pmid:22339318 |
Kim D et al. | Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:22733296 |
Kakiya N et al. | Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. | 2012 | J. Biol. Chem. | pmid:22767595 |
Li Y et al. | Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22451389 |
Wang F et al. | Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin. | 2012 | J. Microbiol. | pmid:23124744 |
Liu S et al. | SHP2 is a target of the immunosuppressant tautomycetin. | 2011 | Chem. Biol. | pmid:21276943 |
Wee YM et al. | The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model. | 2010 Jul-Aug | Mol. Med. | pmid:20440443 |
Walsh JE and Young MR | Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells. | 2010 | Anticancer Res. | pmid:21187463 |
Scaglione JB et al. | Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. | 2010 | Angew. Chem. Int. Ed. Engl. | pmid:20623733 |
Luo Y et al. | Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. | 2010 | J. Am. Chem. Soc. | pmid:20426415 |