MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.
To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Tautomycetin
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Thyroid Neoplasms | D013964 | 33 associated lipids |
Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lee JH et al. | Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. | 2006 | Mol. Cancer Ther. | pmid:17172426 |
Kim JH et al. | Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. | 2005 | Transplant. Proc. | pmid:15919517 |
Chae WJ et al. | T Cell-specific immunosuppression using tautomycetin or PTD-conjugated protein drugs. | 2004 | Yonsei Med. J. | pmid:15627288 |
Han DJ et al. | Tautomycetin as a novel immunosuppressant in transplantation. | 2003 | Transplant. Proc. | pmid:12591525 |
Mitsuhashi S et al. | Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. | 2003 | J. Biol. Chem. | pmid:12374792 |
Myles DC | Novel biologically active natural and unnatural products. | 2003 | Curr. Opin. Biotechnol. | pmid:14662393 |
Shim JH et al. | Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12149481 |
Oikawa H | Synthesis of specific protein phosphatase inhibitors, tautomycin and tautomycetin toward structure-activity relationship study. | 2002 | Curr. Med. Chem. | pmid:12369869 |
Mitsuhashi S | [Structure and function of a novel PP-1 specific inhibitor, tautomycetin]. | 2002 | Seikagaku | pmid:12510378 |
Mitsuhashi S et al. | Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554729 |