Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.

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To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tautomycetin?

Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tautomycetin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Tautomycetin

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tautomycetin?

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What functions are associated with Tautomycetin?

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Function Cross reference Weighted score Related literatures

What lipids are associated with Tautomycetin?

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What genes are associated with Tautomycetin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tautomycetin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Tautomycetin

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Authors Title Published Journal PubMed Link
Ubukata M The logic of biologically active small molecules: amazing ability of microorganisms. 2018 Biosci. Biotechnol. Biochem. pmid:29561233
Choy MS et al. PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. 2017 J. Am. Chem. Soc. pmid:29156132
Choi SS et al. Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412. 2017 J. Ind. Microbiol. Biotechnol. pmid:27734184
Li M et al. TmcN is involved in ATP regulation of tautomycetin biosynthesis in Streptomyces griseochromogenes. 2016 Biochem. Biophys. Res. Commun. pmid:27444385
Tripathi A et al. Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. 2016 J. Ind. Microbiol. Biotechnol. pmid:27277081
Stockwell J et al. Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury. 2016 Neuropharmacology pmid:26626486
Gu M et al. Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation. 2014 J. Immunol. pmid:24534530
An BC et al. Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli. 2014 Biochemistry pmid:25402663
Niu M et al. Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. 2013 J. Pharmacol. Sci. pmid:23269238
Nah JH et al. Identification and characterization of wblA-dependent tmcT regulation during tautomycetin biosynthesis in Streptomyces sp. CK4412. 2012 Jan-Feb Biotechnol. Adv. pmid:21624452
Yang D et al. Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. 2012 Org. Lett. pmid:22339318
Kim D et al. Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. 2012 J. Ind. Microbiol. Biotechnol. pmid:22733296
Kakiya N et al. Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. 2012 J. Biol. Chem. pmid:22767595
Li Y et al. Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. 2012 Biosci. Biotechnol. Biochem. pmid:22451389
Wang F et al. Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin. 2012 J. Microbiol. pmid:23124744
Liu S et al. SHP2 is a target of the immunosuppressant tautomycetin. 2011 Chem. Biol. pmid:21276943
Wee YM et al. The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model. 2010 Jul-Aug Mol. Med. pmid:20440443
Walsh JE and Young MR Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells. 2010 Anticancer Res. pmid:21187463
Scaglione JB et al. Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. 2010 Angew. Chem. Int. Ed. Engl. pmid:20623733
Luo Y et al. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. 2010 J. Am. Chem. Soc. pmid:20426415
Li W et al. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. 2009 J. Nat. Prod. pmid:19191560
Adler JT et al. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. 2009 Mol. Cancer Ther. pmid:19372564
Ju J et al. Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. 2009 Org. Lett. pmid:19281218
Breton M et al. Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly. 2009 Biophys. Chem. pmid:19744766
Park SH et al. Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. 2009 J. Ind. Microbiol. Biotechnol. pmid:19408025
Hur YA et al. Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. 2008 Microbiology (Reading, Engl.) pmid:18832298
Mitsuhashi S et al. Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation. 2008 Int. J. Oncol. pmid:18949366
Lu Y et al. Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy. 2008 Am. J. Physiol., Cell Physiol. pmid:18094148
Choi SS et al. Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. 2007 Microbiology (Reading, Engl.) pmid:17379718
Swingle M et al. Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. 2007 Methods Mol. Biol. pmid:17200551
Lee JH et al. Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. 2006 Mol. Cancer Ther. pmid:17172426
Kim JH et al. Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. 2005 Transplant. Proc. pmid:15919517
Chae WJ et al. T Cell-specific immunosuppression using tautomycetin or PTD-conjugated protein drugs. 2004 Yonsei Med. J. pmid:15627288
Han DJ et al. Tautomycetin as a novel immunosuppressant in transplantation. 2003 Transplant. Proc. pmid:12591525
Mitsuhashi S et al. Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. 2003 J. Biol. Chem. pmid:12374792
Myles DC Novel biologically active natural and unnatural products. 2003 Curr. Opin. Biotechnol. pmid:14662393
Shim JH et al. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12149481
Oikawa H Synthesis of specific protein phosphatase inhibitors, tautomycin and tautomycetin toward structure-activity relationship study. 2002 Curr. Med. Chem. pmid:12369869
Mitsuhashi S [Structure and function of a novel PP-1 specific inhibitor, tautomycetin]. 2002 Seikagaku pmid:12510378
Mitsuhashi S et al. Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. 2001 Biochem. Biophys. Res. Commun. pmid:11554729
Sakuda S et al. Isolation of tautomycetin as a regulator of secondary metabolite production for Penicillium urticae. 1995 Biosci. Biotechnol. Biochem. pmid:7765963
Cheng XC et al. The structure of tautomycetin, a dialkylmaleic anhydride antibiotic. 1990 J. Antibiot. pmid:2387780
Cheng XC et al. A new antibiotic, tautomycetin. 1989 J. Antibiot. pmid:2921220