Mitsuhashi S et al. |
Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. |
2003 |
J. Biol. Chem. |
pmid:12374792
|
Kakiya N et al. |
Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. |
2012 |
J. Biol. Chem. |
pmid:22767595
|
Gu M et al. |
Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation. |
2014 |
J. Immunol. |
pmid:24534530
|
Choi SS et al. |
Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412. |
2017 |
J. Ind. Microbiol. Biotechnol. |
pmid:27734184
|
Park SH et al. |
Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. |
2009 |
J. Ind. Microbiol. Biotechnol. |
pmid:19408025
|
Kim D et al. |
Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. |
2012 |
J. Ind. Microbiol. Biotechnol. |
pmid:22733296
|
Tripathi A et al. |
Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. |
2016 |
J. Ind. Microbiol. Biotechnol. |
pmid:27277081
|
Wang F et al. |
Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin. |
2012 |
J. Microbiol. |
pmid:23124744
|
Li W et al. |
Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. |
2009 |
J. Nat. Prod. |
pmid:19191560
|
Niu M et al. |
Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. |
2013 |
J. Pharmacol. Sci. |
pmid:23269238
|
Swingle M et al. |
Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. |
2007 |
Methods Mol. Biol. |
pmid:17200551
|
Hur YA et al. |
Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. |
2008 |
Microbiology (Reading, Engl.) |
pmid:18832298
|
Choi SS et al. |
Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. |
2007 |
Microbiology (Reading, Engl.) |
pmid:17379718
|
Adler JT et al. |
Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. |
2009 |
Mol. Cancer Ther. |
pmid:19372564
|
Lee JH et al. |
Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. |
2006 |
Mol. Cancer Ther. |
pmid:17172426
|
Wee YM et al. |
The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model. |
2010 Jul-Aug |
Mol. Med. |
pmid:20440443
|
Stockwell J et al. |
Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury. |
2016 |
Neuropharmacology |
pmid:26626486
|
Ju J et al. |
Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. |
2009 |
Org. Lett. |
pmid:19281218
|
Yang D et al. |
Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. |
2012 |
Org. Lett. |
pmid:22339318
|
Shim JH et al. |
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. |
2002 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:12149481
|