Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| López-Gallardo E et al. | Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations. | 2018 | Food Chem. Toxicol. | pmid:29991444 |
| Shi JF et al. | Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. | 2014 | Eur J Med Chem | pmid:24308999 |
| Masuya T et al. | Pinpoint chemical modification of Asp160 in the 49 kDa subunit of bovine mitochondrial complex I via a combination of ligand-directed tosyl chemistry and click chemistry. | 2014 | Biochemistry | pmid:25419630 |
| Chen Y et al. | Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. | 2012 | J Ethnopharmacol | pmid:22609808 |
| Chen Y et al. | Determination of bullatacin in rat plasma by liquid chromatography-mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22534655 |
| Alasbahi RH and Melzig MF | Forskolin and derivatives as tools for studying the role of cAMP. | 2012 | Pharmazie | pmid:22393824 |
| Meyer KJ et al. | Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. | 2012 | Mar Drugs | pmid:22690150 |
| Chen Y et al. | Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa. | 2011 | J. Nat. Prod. | pmid:22011319 |
| Ferreira JF et al. | In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis: trematocidal plant alcoholic extracts. | 2011 | Parasitol. Res. | pmid:21562762 |
| Nakanishi S et al. | Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase. | 2011 | Biochim. Biophys. Acta | pmid:21616052 |