Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Carelli V et al. | Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy. | 1999 | Ann. Neurol. | pmid:10072046 |
| Schuler F et al. | NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10097178 |
| Myers MA et al. | Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells. | 1999 | Autoimmunity | pmid:10433094 |
| Tormo JR et al. | Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins. | 1999 | Arch. Biochem. Biophys. | pmid:10462447 |
| Liaw CC et al. | New annonaceous acetogenins from Rollinia mucosa. | 1999 | J. Nat. Prod. | pmid:10654411 |
| Fu LW et al. | Circumvention of tumor multidrug resistance by a new annonaceous acetogenin: atemoyacin-B. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678092 |
| Avedissian H et al. | Total synthesis of asimicin and bullatacin. | 2000 | J. Org. Chem. | pmid:10987938 |
| Takada M et al. | Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I. | 2000 | Biochim. Biophys. Acta | pmid:11106771 |
| Tormo JR et al. | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11266168 |