Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Duval RA et al. | Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins. | 2006 | Biochemistry | pmid:16489765 |
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| Tinsley JM et al. | Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane. | 2005 | Org. Lett. | pmid:16146398 |
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| Hamada T et al. | Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I. | 2004 | Biochemistry | pmid:15035635 |
| Chiu HF et al. | Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells. | 2003 | Biochem. Pharmacol. | pmid:12527325 |
| Marshall JA et al. | A modular synthesis of annonaceous acetogenins. | 2003 | J. Org. Chem. | pmid:12608790 |
| Royo I et al. | In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I. | 2003 | Oncol. Res. | pmid:12899242 |
| Chang FR et al. | New adjacent Bis-tetrahydrofuran Annonaceous acetogenins from Annona muricata. | 2003 | Planta Med. | pmid:12677528 |
| González-Coloma A et al. | Selective action of acetogenin mitochondrial complex I inhibitors. | 2002 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:12562089 |
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| Xu ZF et al. | [Inhibition of oxygen consumption by annonaceous acetogenins in liver cell respiration and their structure-activity relationship]. | 2002 | Yao Xue Xue Bao | pmid:12567869 |
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| Chih HW et al. | Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. | 2001 | Life Sci. | pmid:11521756 |
| Tormo JR et al. | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11266168 |
| Takada M et al. | Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I. | 2000 | Biochim. Biophys. Acta | pmid:11106771 |
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| Carelli V et al. | Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy. | 1999 | Ann. Neurol. | pmid:10072046 |
| Schuler F et al. | NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10097178 |
| Myers MA et al. | Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells. | 1999 | Autoimmunity | pmid:10433094 |
| Tormo JR et al. | Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins. | 1999 | Arch. Biochem. Biophys. | pmid:10462447 |
| Liaw CC et al. | New annonaceous acetogenins from Rollinia mucosa. | 1999 | J. Nat. Prod. | pmid:10654411 |
| Fu LW et al. | Circumvention of tumor multidrug resistance by a new annonaceous acetogenin: atemoyacin-B. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678092 |
| Okun JG et al. | Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). | 1999 | J. Biol. Chem. | pmid:9915790 |
| Alali FQ et al. | Annonaceous acetogenins as natural pesticides: potent toxicity against insecticide-susceptible and -resistant German cockroaches (Dictyoptera: Blattellidae). | 1998 | J. Econ. Entomol. | pmid:9650513 |
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| Shimada H et al. | Membrane conformations and their relation to cytotoxicity of asimicin and its analogues. | 1998 | Biochemistry | pmid:9454575 |
| Estornell E et al. | Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I). | 1997 | Biochem. Biophys. Res. Commun. | pmid:9367916 |
| Carelli V et al. | Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype. | 1997 | Neurology | pmid:9191778 |
| Oberlies NH et al. | Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. | 1997 | J. Med. Chem. | pmid:9207950 |
| Oberlies NH et al. | The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. | 1997 | Cancer Lett. | pmid:9097981 |
| Darrouzet E and Dupuis A | Genetic evidence for the existence of two quinone related inhibitor binding sites in NADH-CoQ reductase. | 1997 | Biochim. Biophys. Acta | pmid:9107311 |
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| Zhao GX et al. | The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba. | 1996 | Bioorg. Med. Chem. | pmid:8689234 |
| Morré DJ et al. | Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. | 1995 | Life Sci. | pmid:7837933 |
| Degli Esposti M et al. | Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I). | 1994 | Biochem. J. | pmid:8037664 |
| Holschneider CH et al. | Bullatacin--in vivo and in vitro experience in an ovarian cancer model. | 1994 | Cancer Chemother. Pharmacol. | pmid:8194168 |
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| Li XH et al. | Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa. | 1990 Jan-Feb | J. Nat. Prod. | pmid:2348205 |
| Hui YH et al. | Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata. | 1989 May-Jun | J. Nat. Prod. | pmid:2778448 |
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