Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tormo JR et al. | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11266168 |
| Holschneider CH et al. | Bullatacin--in vivo and in vitro experience in an ovarian cancer model. | 1994 | Cancer Chemother. Pharmacol. | pmid:8194168 |
| Oberlies NH et al. | The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. | 1997 | Cancer Lett. | pmid:9097981 |
| Shi JF et al. | Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. | 2014 | Eur J Med Chem | pmid:24308999 |
| Wiart C | Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections? | 2007 | Evid Based Complement Alternat Med | pmid:17965760 |
| Nakamaru-Ogiso E et al. | The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. | 2010 | FEBS Lett. | pmid:20074573 |
| López-Gallardo E et al. | Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations. | 2018 | Food Chem. Toxicol. | pmid:29991444 |
| Kuete V and Efferth T | Cameroonian medicinal plants: pharmacology and derived natural products. | 2010 | Front Pharmacol | pmid:21833168 |
| Chen Y et al. | Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. | 2012 | J Ethnopharmacol | pmid:22609808 |
| Pomper KW et al. | Identification of annonaceous acetogenins in the ripe fruit of the North American pawpaw ( Asimina triloba ). | 2009 | J. Agric. Food Chem. | pmid:19711911 |