Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kuete V and Efferth T | Cameroonian medicinal plants: pharmacology and derived natural products. | 2010 | Front Pharmacol | pmid:21833168 |
| López-Gallardo E et al. | Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations. | 2018 | Food Chem. Toxicol. | pmid:29991444 |
| Nakamaru-Ogiso E et al. | The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. | 2010 | FEBS Lett. | pmid:20074573 |
| Wiart C | Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections? | 2007 | Evid Based Complement Alternat Med | pmid:17965760 |
| Shi JF et al. | Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. | 2014 | Eur J Med Chem | pmid:24308999 |
| Oberlies NH et al. | The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. | 1997 | Cancer Lett. | pmid:9097981 |
| Holschneider CH et al. | Bullatacin--in vivo and in vitro experience in an ovarian cancer model. | 1994 | Cancer Chemother. Pharmacol. | pmid:8194168 |
| Tormo JR et al. | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11266168 |
| Makabe H et al. | Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I. | 2006 | Bioorg. Med. Chem. | pmid:16431114 |
| Zhao GX et al. | The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba. | 1996 | Bioorg. Med. Chem. | pmid:8689234 |
| Takada M et al. | Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I. | 2000 | Biochim. Biophys. Acta | pmid:11106771 |
| Fato R et al. | Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. | 2009 | Biochim. Biophys. Acta | pmid:19059197 |
| Nakanishi S et al. | Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase. | 2011 | Biochim. Biophys. Acta | pmid:21616052 |
| Darrouzet E and Dupuis A | Genetic evidence for the existence of two quinone related inhibitor binding sites in NADH-CoQ reductase. | 1997 | Biochim. Biophys. Acta | pmid:9107311 |
| Shimada H et al. | Membrane conformations and their relation to cytotoxicity of asimicin and its analogues. | 1998 | Biochemistry | pmid:9454575 |
| Kakutani N et al. | Exploring the binding site of delta(lac)-acetogenin in bovine heart mitochondrial NADH-ubiquinone oxidoreductase. | 2010 | Biochemistry | pmid:20459120 |
| Hamada T et al. | Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I. | 2004 | Biochemistry | pmid:15035635 |
| Masuya T et al. | Pinpoint chemical modification of Asp160 in the 49 kDa subunit of bovine mitochondrial complex I via a combination of ligand-directed tosyl chemistry and click chemistry. | 2014 | Biochemistry | pmid:25419630 |
| Duval RA et al. | Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins. | 2006 | Biochemistry | pmid:16489765 |
| Ichimaru N et al. | Synthesis and inhibition mechanism of Delta lac-acetogenins, a novel type of inhibitor of bovine heart mitochondrial complex I. | 2005 | Biochemistry | pmid:15641810 |