Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chih HW et al. | Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. | 2001 | Life Sci. | pmid:11521756 |
| Ahammadsahib KI et al. | Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin. | 1993 | Life Sci. | pmid:8371627 |
| Meyer KJ et al. | Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. | 2012 | Mar Drugs | pmid:22690150 |
| Luna-Cazares LM and Gonzalez-Esquinca AR | Susceptibility of complete bacteria and spheroplasts of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi to rolliniastatin-2. | 2010 | Nat. Prod. Res. | pmid:20582808 |
| Carelli V et al. | Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype. | 1997 | Neurology | pmid:9191778 |
| Royo I et al. | In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I. | 2003 | Oncol. Res. | pmid:12899242 |
| Marshall JA and Sabatini JJ | An outside-in approach to adjacent bistetrahydrofuran annonaceous acetogenins with C2 core symmetry. Total synthesis of asimicin and a C32 analogue. | 2006 | Org. Lett. | pmid:16869659 |
| Zhao H et al. | Advances in Lewis acid controlled carbon-carbon bond-forming reactions enable a concise and convergent total synthesis of bullatacin. | 2006 | Org. Lett. | pmid:16956231 |
| Tinsley JM et al. | Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane. | 2005 | Org. Lett. | pmid:16146398 |
| Ferreira JF et al. | In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis: trematocidal plant alcoholic extracts. | 2011 | Parasitol. Res. | pmid:21562762 |