| MeSH term | MeSH ID | Detail |
|---|---|---|
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
| Tauopathies | D024801 | 6 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Epothilone D
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone D?
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone D
PubChem Associated disorders and diseases
What pathways are associated with Epothilone D
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone D?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone D?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone D?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone D
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang C et al. | Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19775943 |
| Yuan L et al. | Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25151331 |
| Hause G et al. | Epothilone D affects cell cycle and microtubular pattern in plant cells. | 2005 | J. Exp. Bot. | pmid:15967777 |
| Ye W et al. | A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26803504 |
| Hardt IH et al. | New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | 2001 | J. Nat. Prod. | pmid:11473410 |
| Arslanian RL et al. | A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. | 2002 | J. Nat. Prod. | pmid:12141877 |
| Arslanian RL et al. | Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. | 2002 | J. Nat. Prod. | pmid:11975503 |
| Starks CM et al. | Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. | 2003 | J. Nat. Prod. | pmid:14575429 |
| Verrills NM et al. | Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | 2006 | J. Natl. Cancer Inst. | pmid:17018783 |
| Killinger BA and Moszczynska A | Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. | 2016 | J. Neurochem. | pmid:26465779 |
| Fournet V et al. | Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. | 2012 | J. Neurochem. | pmid:23013328 |
| Dietzmann A et al. | Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton. | 2003 | J. Neurooncol. | pmid:14686728 |
| Brunden KR et al. | Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. | 2010 | J. Neurosci. | pmid:20943926 |
| Barten DM et al. | Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. | 2012 | J. Neurosci. | pmid:22623658 |
| Zhang B et al. | The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. | 2012 | J. Neurosci. | pmid:22423084 |
| Chappell MD et al. | Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. | 2002 | J. Org. Chem. | pmid:12398496 |
| Rivkin A et al. | Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. | 2002 | J. Org. Chem. | pmid:12398497 |
| Mulzer J et al. | Total syntheses of epothilones B and D. | 2000 | J. Org. Chem. | pmid:11076603 |
| Jung JC et al. | Total syntheses of epothilones B and d. | 2004 | J. Org. Chem. | pmid:15609966 |
| Wessjohann LA et al. | Total synthesis of epothilone D: the nerol/macroaldolization approach. | 2013 | J. Org. Chem. | pmid:24079664 |