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Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. |
2012 |
Invest New Drugs |
pmid:22072399
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Monk JP et al. |
A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors. |
2012 |
Invest New Drugs |
pmid:21826439
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Brunden KR et al. |
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. |
2011 |
Pharmacol. Res. |
pmid:21163349
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Nakano M et al. |
Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. |
2011 |
Mol. Cell Proteomics |
pmid:21859949
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Brunden KR et al. |
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. |
2010 |
J. Neurosci. |
pmid:20943926
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Prantz K and Mulzer J |
Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A. |
2010 |
Chemistry |
pmid:19943284
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Zhang SQ et al. |
Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry. |
2009 |
Biomed. Chromatogr. |
pmid:18800336
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Zhang C et al. |
Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. |
2009 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:19775943
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Prantz K and Mulzer J |
Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D. |
2009 |
Angew. Chem. Int. Ed. Engl. |
pmid:19492384
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Frein JD et al. |
New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue. |
2009 |
Org. Lett. |
pmid:19572566
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Keck GE et al. |
Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions. |
2008 |
J. Org. Chem. |
pmid:18991385
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Chen QH et al. |
Design, synthesis and biological evaluation of bridged epothilone D analogues. |
2008 |
Org. Biomol. Chem. |
pmid:19039362
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Harrison M and Swanton C |
Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. |
2008 |
Expert Opin Investig Drugs |
pmid:18363517
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Burris HA |
Preclinical investigations with epothilones in breast cancer models. |
2008 |
Semin. Oncol. |
pmid:18410795
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Vahdat LT |
Clinical studies with epothilones for the treatment of metastatic breast cancer. |
2008 |
Semin. Oncol. |
pmid:18410796
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Lee SH et al. |
Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. |
2007 |
Mol. Cancer Ther. |
pmid:17938270
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Fumoleau P et al. |
Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. |
2007 |
Ann. Oncol. |
pmid:17656562
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Kim TJ et al. |
Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. |
2007 |
Vascul. Pharmacol. |
pmid:17706465
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Beer TM et al. |
Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel. |
2007 |
Invest New Drugs |
pmid:17618407
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Mutka SC et al. |
Heterologous production of epothilone C and D in Escherichia coli. |
2006 |
Biochemistry |
pmid:16430229
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