Chen QH et al. |
Design, synthesis and biological evaluation of bridged epothilone D analogues. |
2008 |
Org. Biomol. Chem. |
pmid:19039362
|
Prantz K and Mulzer J |
Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D. |
2009 |
Angew. Chem. Int. Ed. Engl. |
pmid:19492384
|
Frein JD et al. |
New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue. |
2009 |
Org. Lett. |
pmid:19572566
|
Zhang C et al. |
Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. |
2009 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:19775943
|
Prantz K and Mulzer J |
Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A. |
2010 |
Chemistry |
pmid:19943284
|
Brunden KR et al. |
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. |
2010 |
J. Neurosci. |
pmid:20943926
|
Brunden KR et al. |
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. |
2011 |
Pharmacol. Res. |
pmid:21163349
|
Monk JP et al. |
A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors. |
2012 |
Invest New Drugs |
pmid:21826439
|
Nakano M et al. |
Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. |
2011 |
Mol. Cell Proteomics |
pmid:21859949
|
Konner J et al. |
Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. |
2012 |
Invest New Drugs |
pmid:22072399
|
Zhang B et al. |
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. |
2012 |
J. Neurosci. |
pmid:22423084
|
Barten DM et al. |
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. |
2012 |
J. Neurosci. |
pmid:22623658
|
Brunden KR et al. |
Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. |
2012 |
Biochem. Soc. Trans. |
pmid:22817712
|
Fournet V et al. |
Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. |
2012 |
J. Neurochem. |
pmid:23013328
|
Wang C et al. |
Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. |
2013 |
Angew. Chem. Int. Ed. Engl. |
pmid:23307513
|
Xiong Y et al. |
HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23487739
|
Cartelli D et al. |
Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. |
2013 |
Sci Rep |
pmid:23670541
|
Sang F et al. |
Epothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities. |
2013 |
Eur J Med Chem |
pmid:23994325
|
Wessjohann LA et al. |
Total synthesis of epothilone D: the nerol/macroaldolization approach. |
2013 |
J. Org. Chem. |
pmid:24079664
|
Brunden KR et al. |
MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. |
2013 |
ACS Med Chem Lett |
pmid:24900764
|
Yuan L et al. |
Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. |
2014 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:25151331
|
Brizuela M et al. |
The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro. |
2015 |
Mol. Cell. Neurosci. |
pmid:25684676
|
Burrell RC et al. |
Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach. |
2015 |
J Labelled Comp Radiopharm |
pmid:26158758
|
Killinger BA and Moszczynska A |
Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. |
2016 |
J. Neurochem. |
pmid:26465779
|
Bakota L and Brandt R |
Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. |
2016 |
Drugs |
pmid:26729186
|
Penazzi L et al. |
Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. |
2016 |
Neuropharmacology |
pmid:26772969
|
Ye W et al. |
A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. |
2016 |
J. Ind. Microbiol. Biotechnol. |
pmid:26803504
|
Haydl AM and Breit B |
The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies. |
2017 |
Chemistry |
pmid:27792853
|
Woods LM et al. |
Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues. |
2017 |
Int J Mol Sci |
pmid:28304361
|
Pchitskaya EI et al. |
Dynamic Microtubules in Alzheimer's Disease: Association with Dendritic Spine Pathology. |
2018 |
Biochemistry Mosc. |
pmid:30472945
|
Chou TC et al. |
Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9689134
|
Chou TC et al. |
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9861050
|