MeSH term | MeSH ID | Detail |
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Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kim TJ et al. | Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. | 2007 | Vascul. Pharmacol. | pmid:17706465 |
Burris HA | Preclinical investigations with epothilones in breast cancer models. | 2008 | Semin. Oncol. | pmid:18410795 |
Vahdat LT | Clinical studies with epothilones for the treatment of metastatic breast cancer. | 2008 | Semin. Oncol. | pmid:18410796 |
Cartelli D et al. | Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. | 2013 | Sci Rep | pmid:23670541 |
Altmann KH et al. | 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. | 2004 | Prog Med Chem | pmid:15003721 |
Chou TC et al. | Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689134 |
Chou TC et al. | Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9861050 |
Lichtner RB et al. | Subcellular distribution of epothilones in human tumor cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562452 |
Chou TC et al. | The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11438750 |
Xiong Y et al. | HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487739 |
Brunden KR et al. | The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. | 2011 | Pharmacol. Res. | pmid:21163349 |
Chappell MD et al. | En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. | 2000 | Org. Lett. | pmid:10841497 |
Stachel SJ et al. | On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. | 2000 | Org. Lett. | pmid:10841498 |
Taylor RE and Chen Y | Total synthesis of epothilones B and D. | 2001 | Org. Lett. | pmid:11440584 |
Frein JD et al. | New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue. | 2009 | Org. Lett. | pmid:19572566 |
Gaich T and Mulzer J | Synthesis of epothilones via a silicon-tethered RCM reaction. | 2005 | Org. Lett. | pmid:15787494 |
Chen QH et al. | Design, synthesis and biological evaluation of bridged epothilone D analogues. | 2008 | Org. Biomol. Chem. | pmid:19039362 |
Penazzi L et al. | Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. | 2016 | Neuropharmacology | pmid:26772969 |
Brizuela M et al. | The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro. | 2015 | Mol. Cell. Neurosci. | pmid:25684676 |
Nakano M et al. | Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. | 2011 | Mol. Cell Proteomics | pmid:21859949 |
Lee SH et al. | Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. | 2007 | Mol. Cancer Ther. | pmid:17938270 |
Chappell MD et al. | Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. | 2002 | J. Org. Chem. | pmid:12398496 |
Rivkin A et al. | Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. | 2002 | J. Org. Chem. | pmid:12398497 |
Mulzer J et al. | Total syntheses of epothilones B and D. | 2000 | J. Org. Chem. | pmid:11076603 |
Keck GE et al. | Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions. | 2008 | J. Org. Chem. | pmid:18991385 |
Jung JC et al. | Total syntheses of epothilones B and d. | 2004 | J. Org. Chem. | pmid:15609966 |
Wessjohann LA et al. | Total synthesis of epothilone D: the nerol/macroaldolization approach. | 2013 | J. Org. Chem. | pmid:24079664 |
Brunden KR et al. | Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. | 2010 | J. Neurosci. | pmid:20943926 |
Barten DM et al. | Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. | 2012 | J. Neurosci. | pmid:22623658 |
Zhang B et al. | The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. | 2012 | J. Neurosci. | pmid:22423084 |
Dietzmann A et al. | Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton. | 2003 | J. Neurooncol. | pmid:14686728 |
Killinger BA and Moszczynska A | Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. | 2016 | J. Neurochem. | pmid:26465779 |
Fournet V et al. | Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. | 2012 | J. Neurochem. | pmid:23013328 |
Verrills NM et al. | Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | 2006 | J. Natl. Cancer Inst. | pmid:17018783 |
Hardt IH et al. | New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | 2001 | J. Nat. Prod. | pmid:11473410 |
Arslanian RL et al. | A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. | 2002 | J. Nat. Prod. | pmid:12141877 |
Arslanian RL et al. | Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. | 2002 | J. Nat. Prod. | pmid:11975503 |
Starks CM et al. | Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. | 2003 | J. Nat. Prod. | pmid:14575429 |
Ye W et al. | A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26803504 |
Hause G et al. | Epothilone D affects cell cycle and microtubular pattern in plant cells. | 2005 | J. Exp. Bot. | pmid:15967777 |
Zhang C et al. | Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19775943 |
Yuan L et al. | Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25151331 |
Nagano S et al. | Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. | 2003 | J. Biol. Chem. | pmid:12933799 |
Tang L et al. | Generation of novel epothilone analogs with cytotoxic activity by biotransformation. | 2003 | J. Antibiot. | pmid:12670045 |
White JD et al. | Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. | 2001 | J. Am. Chem. Soc. | pmid:11389619 |
Jumaa M et al. | Kinetics and mechanism of degradation of epothilone-D: an experimental anticancer agent. | 2004 | J Pharm Sci | pmid:15459947 |
Wang Z et al. | Determination of desoxyepothilone B in nude mice plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography. | 2006 | J Pharm Biomed Anal | pmid:16616824 |
Burrell RC et al. | Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach. | 2015 | J Labelled Comp Radiopharm | pmid:26158758 |
Bergstralh DT et al. | A comparison of signaling activities induced by Taxol and desoxyepothilone B. | 2004 | J Chemother | pmid:15700849 |
Monk JP et al. | A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors. | 2012 | Invest New Drugs | pmid:21826439 |