MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lee SH et al. | Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. | 2007 | Mol. Cancer Ther. | pmid:17938270 |
Chappell MD et al. | Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. | 2002 | J. Org. Chem. | pmid:12398496 |
Rivkin A et al. | Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. | 2002 | J. Org. Chem. | pmid:12398497 |
Mulzer J et al. | Total syntheses of epothilones B and D. | 2000 | J. Org. Chem. | pmid:11076603 |
Keck GE et al. | Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions. | 2008 | J. Org. Chem. | pmid:18991385 |
Jung JC et al. | Total syntheses of epothilones B and d. | 2004 | J. Org. Chem. | pmid:15609966 |
Wessjohann LA et al. | Total synthesis of epothilone D: the nerol/macroaldolization approach. | 2013 | J. Org. Chem. | pmid:24079664 |
Brunden KR et al. | Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. | 2010 | J. Neurosci. | pmid:20943926 |
Barten DM et al. | Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. | 2012 | J. Neurosci. | pmid:22623658 |
Zhang B et al. | The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. | 2012 | J. Neurosci. | pmid:22423084 |