MeSH term | MeSH ID | Detail |
---|---|---|
Tauopathies | D024801 | 6 associated lipids |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kim TJ et al. | Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. | 2007 | Vascul. Pharmacol. | pmid:17706465 |
Burris HA | Preclinical investigations with epothilones in breast cancer models. | 2008 | Semin. Oncol. | pmid:18410795 |
Vahdat LT | Clinical studies with epothilones for the treatment of metastatic breast cancer. | 2008 | Semin. Oncol. | pmid:18410796 |
Cartelli D et al. | Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. | 2013 | Sci Rep | pmid:23670541 |
Altmann KH et al. | 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. | 2004 | Prog Med Chem | pmid:15003721 |
Chou TC et al. | Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689134 |
Chou TC et al. | Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9861050 |
Lichtner RB et al. | Subcellular distribution of epothilones in human tumor cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562452 |
Chou TC et al. | The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11438750 |
Xiong Y et al. | HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487739 |
Brunden KR et al. | The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. | 2011 | Pharmacol. Res. | pmid:21163349 |
Chappell MD et al. | En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. | 2000 | Org. Lett. | pmid:10841497 |
Stachel SJ et al. | On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. | 2000 | Org. Lett. | pmid:10841498 |
Taylor RE and Chen Y | Total synthesis of epothilones B and D. | 2001 | Org. Lett. | pmid:11440584 |
Frein JD et al. | New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue. | 2009 | Org. Lett. | pmid:19572566 |
Gaich T and Mulzer J | Synthesis of epothilones via a silicon-tethered RCM reaction. | 2005 | Org. Lett. | pmid:15787494 |
Chen QH et al. | Design, synthesis and biological evaluation of bridged epothilone D analogues. | 2008 | Org. Biomol. Chem. | pmid:19039362 |
Penazzi L et al. | Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. | 2016 | Neuropharmacology | pmid:26772969 |
Brizuela M et al. | The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro. | 2015 | Mol. Cell. Neurosci. | pmid:25684676 |
Nakano M et al. | Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. | 2011 | Mol. Cell Proteomics | pmid:21859949 |