MeSH term | MeSH ID | Detail |
---|---|---|
Tauopathies | D024801 | 6 associated lipids |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mutka SC et al. | Heterologous production of epothilone C and D in Escherichia coli. | 2006 | Biochemistry | pmid:16430229 |
Verrills NM et al. | Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | 2006 | J. Natl. Cancer Inst. | pmid:17018783 |
Wang Z et al. | Determination of desoxyepothilone B in nude mice plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography. | 2006 | J Pharm Biomed Anal | pmid:16616824 |
Frykman SA et al. | Assessment of fed-batch, semicontinuous, and continuous epothilone D production processes. | 2005 Jul-Aug | Biotechnol. Prog. | pmid:16080689 |
Gaich T and Mulzer J | Synthesis of epothilones via a silicon-tethered RCM reaction. | 2005 | Org. Lett. | pmid:15787494 |
Wang H et al. | Preclinical pharmacology of epothilone D, a novel tubulin-stabilizing antitumor agent. | 2005 | Cancer Chemother. Pharmacol. | pmid:15868148 |
Broadrup RL et al. | Total synthesis of 12,13-desoxyepothilone B (Epothilone D). | 2005 | Bioorg. Chem. | pmid:15788167 |
Hause G et al. | Epothilone D affects cell cycle and microtubular pattern in plant cells. | 2005 | J. Exp. Bot. | pmid:15967777 |
Kolman A | Epothilone D (Kosan/Roche). | 2004 | Curr Opin Investig Drugs | pmid:15242255 |
Schinzer D et al. | Synthesis of furano-epothilone D. | 2004 | Chemistry | pmid:15224330 |
Jung JC et al. | Total syntheses of epothilones B and d. | 2004 | J. Org. Chem. | pmid:15609966 |
Altmann KH et al. | 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. | 2004 | Prog Med Chem | pmid:15003721 |
Jumaa M et al. | Kinetics and mechanism of degradation of epothilone-D: an experimental anticancer agent. | 2004 | J Pharm Sci | pmid:15459947 |
Bergstralh DT et al. | A comparison of signaling activities induced by Taxol and desoxyepothilone B. | 2004 | J Chemother | pmid:15700849 |
End N et al. | Total synthesis and biological evaluation of a C(10)/C(12)-phenylene-bridged analog of epothilone D. | 2004 | Chem. Biodivers. | pmid:17191815 |
Tang L et al. | Generation of novel epothilone analogs with cytotoxic activity by biotransformation. | 2003 | J. Antibiot. | pmid:12670045 |
Kealey JT | Creating polyketide diversity through genetic engineering. | 2003 | Front. Biosci. | pmid:12456305 |
Nagano S et al. | Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. | 2003 | J. Biol. Chem. | pmid:12933799 |
Verrills NM et al. | Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions. | 2003 | Chem. Biol. | pmid:12890533 |
Dietzmann A et al. | Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton. | 2003 | J. Neurooncol. | pmid:14686728 |