MeSH term | MeSH ID | Detail |
---|---|---|
Tauopathies | D024801 | 6 associated lipids |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Verrills NM et al. | Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | 2006 | J. Natl. Cancer Inst. | pmid:17018783 |
Wang Z et al. | Determination of desoxyepothilone B in nude mice plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography. | 2006 | J Pharm Biomed Anal | pmid:16616824 |
Kuppens IE | Current state of the art of new tubulin inhibitors in the clinic. | 2006 | Curr Clin Pharmacol | pmid:18666378 |
Frykman SA et al. | Assessment of fed-batch, semicontinuous, and continuous epothilone D production processes. | 2005 Jul-Aug | Biotechnol. Prog. | pmid:16080689 |
Gaich T and Mulzer J | Synthesis of epothilones via a silicon-tethered RCM reaction. | 2005 | Org. Lett. | pmid:15787494 |
Wang H et al. | Preclinical pharmacology of epothilone D, a novel tubulin-stabilizing antitumor agent. | 2005 | Cancer Chemother. Pharmacol. | pmid:15868148 |
Broadrup RL et al. | Total synthesis of 12,13-desoxyepothilone B (Epothilone D). | 2005 | Bioorg. Chem. | pmid:15788167 |
Hause G et al. | Epothilone D affects cell cycle and microtubular pattern in plant cells. | 2005 | J. Exp. Bot. | pmid:15967777 |
Bergstralh DT et al. | A comparison of signaling activities induced by Taxol and desoxyepothilone B. | 2004 | J Chemother | pmid:15700849 |
End N et al. | Total synthesis and biological evaluation of a C(10)/C(12)-phenylene-bridged analog of epothilone D. | 2004 | Chem. Biodivers. | pmid:17191815 |