MeSH term | MeSH ID | Detail |
---|---|---|
Tauopathies | D024801 | 6 associated lipids |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid: | ||||
Brunden KR et al. | MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. | 2013 | ACS Med Chem Lett | pmid:24900764 |
Prantz K and Mulzer J | Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19492384 |
Wang C et al. | Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23307513 |
Fumoleau P et al. | Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. | 2007 | Ann. Oncol. | pmid:17656562 |
Julien B and Shah S | Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus. | 2002 | Antimicrob. Agents Chemother. | pmid:12183227 |
Brunden KR et al. | Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. | 2012 | Biochem. Soc. Trans. | pmid:22817712 |
Mutka SC et al. | Heterologous production of epothilone C and D in Escherichia coli. | 2006 | Biochemistry | pmid:16430229 |
Pchitskaya EI et al. | Dynamic Microtubules in Alzheimer's Disease: Association with Dendritic Spine Pathology. | 2018 | Biochemistry Mosc. | pmid:30472945 |
Altmann KH et al. | Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity. | 2000 | Biochim. Biophys. Acta | pmid:10799747 |
Zhang SQ et al. | Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry. | 2009 | Biomed. Chromatogr. | pmid:18800336 |
Broadrup RL et al. | Total synthesis of 12,13-desoxyepothilone B (Epothilone D). | 2005 | Bioorg. Chem. | pmid:15788167 |
Altmann KH et al. | Synthesis and biological evaluation of highly potent analogues of epothilones B and D. | 2000 | Bioorg. Med. Chem. Lett. | pmid:11133086 |
Lau J et al. | Optimizing the heterologous production of epothilone D in Myxococcus xanthus. | 2002 | Biotechnol. Bioeng. | pmid:11920444 |
Frykman SA et al. | Assessment of fed-batch, semicontinuous, and continuous epothilone D production processes. | 2005 Jul-Aug | Biotechnol. Prog. | pmid:16080689 |
Wang H et al. | Preclinical pharmacology of epothilone D, a novel tubulin-stabilizing antitumor agent. | 2005 | Cancer Chemother. Pharmacol. | pmid:15868148 |
End N et al. | Total synthesis and biological evaluation of a C(10)/C(12)-phenylene-bridged analog of epothilone D. | 2004 | Chem. Biodivers. | pmid:17191815 |
Verrills NM et al. | Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions. | 2003 | Chem. Biol. | pmid:12890533 |
Hertweck C | The multiplasmid approach: a new perspective for combinatorial biosynthesis. | 2000 | Chembiochem | pmid:11828403 |
Sinha SC et al. | Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F. | 2001 | Chemistry | pmid:11349910 |
Prantz K and Mulzer J | Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A. | 2010 | Chemistry | pmid:19943284 |
Schinzer D et al. | Synthesis of furano-epothilone D. | 2004 | Chemistry | pmid:15224330 |
Haydl AM and Breit B | The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies. | 2017 | Chemistry | pmid:27792853 |
Kuppens IE | Current state of the art of new tubulin inhibitors in the clinic. | 2006 | Curr Clin Pharmacol | pmid:18666378 |
Kolman A | Epothilone D (Kosan/Roche). | 2004 | Curr Opin Investig Drugs | pmid:15242255 |
Bakota L and Brandt R | Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. | 2016 | Drugs | pmid:26729186 |
Sang F et al. | Epothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities. | 2013 | Eur J Med Chem | pmid:23994325 |
Harrison M and Swanton C | Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. | 2008 | Expert Opin Investig Drugs | pmid:18363517 |
Kealey JT | Creating polyketide diversity through genetic engineering. | 2003 | Front. Biosci. | pmid:12456305 |
Woods LM et al. | Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues. | 2017 | Int J Mol Sci | pmid:28304361 |
Konner J et al. | Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. | 2012 | Invest New Drugs | pmid:22072399 |
Monk JP et al. | A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors. | 2012 | Invest New Drugs | pmid:21826439 |
Beer TM et al. | Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel. | 2007 | Invest New Drugs | pmid:17618407 |
Bergstralh DT et al. | A comparison of signaling activities induced by Taxol and desoxyepothilone B. | 2004 | J Chemother | pmid:15700849 |
Burrell RC et al. | Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach. | 2015 | J Labelled Comp Radiopharm | pmid:26158758 |
Wang Z et al. | Determination of desoxyepothilone B in nude mice plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography. | 2006 | J Pharm Biomed Anal | pmid:16616824 |
Jumaa M et al. | Kinetics and mechanism of degradation of epothilone-D: an experimental anticancer agent. | 2004 | J Pharm Sci | pmid:15459947 |
White JD et al. | Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. | 2001 | J. Am. Chem. Soc. | pmid:11389619 |
Tang L et al. | Generation of novel epothilone analogs with cytotoxic activity by biotransformation. | 2003 | J. Antibiot. | pmid:12670045 |
Nagano S et al. | Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. | 2003 | J. Biol. Chem. | pmid:12933799 |
Zhang C et al. | Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19775943 |
Yuan L et al. | Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25151331 |
Hause G et al. | Epothilone D affects cell cycle and microtubular pattern in plant cells. | 2005 | J. Exp. Bot. | pmid:15967777 |
Ye W et al. | A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26803504 |
Hardt IH et al. | New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | 2001 | J. Nat. Prod. | pmid:11473410 |
Arslanian RL et al. | A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. | 2002 | J. Nat. Prod. | pmid:12141877 |
Arslanian RL et al. | Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. | 2002 | J. Nat. Prod. | pmid:11975503 |
Starks CM et al. | Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. | 2003 | J. Nat. Prod. | pmid:14575429 |
Verrills NM et al. | Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | 2006 | J. Natl. Cancer Inst. | pmid:17018783 |
Fournet V et al. | Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. | 2012 | J. Neurochem. | pmid:23013328 |