MeSH term | MeSH ID | Detail |
---|---|---|
Tauopathies | D024801 | 6 associated lipids |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sinha SC et al. | Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F. | 2001 | Chemistry | pmid:11349910 |
Schinzer D et al. | Synthesis of furano-epothilone D. | 2004 | Chemistry | pmid:15224330 |
Haydl AM and Breit B | The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies. | 2017 | Chemistry | pmid:27792853 |
Kuppens IE | Current state of the art of new tubulin inhibitors in the clinic. | 2006 | Curr Clin Pharmacol | pmid:18666378 |
Kolman A | Epothilone D (Kosan/Roche). | 2004 | Curr Opin Investig Drugs | pmid:15242255 |
Bakota L and Brandt R | Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. | 2016 | Drugs | pmid:26729186 |
Sang F et al. | Epothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities. | 2013 | Eur J Med Chem | pmid:23994325 |
Harrison M and Swanton C | Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. | 2008 | Expert Opin Investig Drugs | pmid:18363517 |
Kealey JT | Creating polyketide diversity through genetic engineering. | 2003 | Front. Biosci. | pmid:12456305 |
Woods LM et al. | Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues. | 2017 | Int J Mol Sci | pmid:28304361 |