MeSH term | MeSH ID | Detail |
---|---|---|
Tauopathies | D024801 | 6 associated lipids |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone D
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Keck GE et al. | Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions. | 2008 | J. Org. Chem. | pmid:18991385 |
Chen QH et al. | Design, synthesis and biological evaluation of bridged epothilone D analogues. | 2008 | Org. Biomol. Chem. | pmid:19039362 |
Harrison M and Swanton C | Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. | 2008 | Expert Opin Investig Drugs | pmid:18363517 |
Burris HA | Preclinical investigations with epothilones in breast cancer models. | 2008 | Semin. Oncol. | pmid:18410795 |
Vahdat LT | Clinical studies with epothilones for the treatment of metastatic breast cancer. | 2008 | Semin. Oncol. | pmid:18410796 |
Lee SH et al. | Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. | 2007 | Mol. Cancer Ther. | pmid:17938270 |
Fumoleau P et al. | Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. | 2007 | Ann. Oncol. | pmid:17656562 |
Kim TJ et al. | Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. | 2007 | Vascul. Pharmacol. | pmid:17706465 |
Beer TM et al. | Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel. | 2007 | Invest New Drugs | pmid:17618407 |
Mutka SC et al. | Heterologous production of epothilone C and D in Escherichia coli. | 2006 | Biochemistry | pmid:16430229 |